α-Conotoxin MII

Name: α-Conotoxin MII
Brand: Tocris Bioscience
SKU: 1340
Price: 740 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 1340

Citations (1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Potent and selective α3β2 and β3 nAChR antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1710.99

View Full Technical Details for α-Conotoxin MII

Biological Activity for α-Conotoxin MII

α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC₅₀ = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.

Licensing Information

Sold under license from the University of Utah.

Technical Data for α-Conotoxin MII

M. Wt	1710.99
Formula	C₆₇H₁₀₃N₂₃O₂₂S₄
Single Letter Sequence	GCCSNPVCHLEHSNLC (Modifications: Disulfide bridges: 2-8, 3-16, Cys-16 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	175735-93-0
PubChem ID	57340508
InChi Key	DUQYFGMBLOPGBY-XCQLYXDWSA-N
Smiles	[H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC2=O)C(N)=O)NC1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-Conotoxin MII

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for α-Conotoxin MII

References are publications that support the biological activity of the product.

David Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur.J.Neurosci. 2010 PMID: 20377613
McIntosh Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function. Eur.J.Pharmacol. 2000 PMID: 10771014
Harvey Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors. Mol.Pharmacol. 1997 PMID: 9203640
Cartier A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J.Biol.Chem. 1996 PMID: 8631783

Citations for α-Conotoxin MII (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for α-Conotoxin MII include:

Krais et al. (2011) CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression. Carcinogenesis. 32:1388
PMID: 21586512

There are no citations that match your criteria.

Showing 1 - 1 of 1 citation Showing All

Product Documents for α-Conotoxin MII

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.