A-7 hydrochloride

Name: A-7 hydrochloride
Brand: tocris
SKU: 0378

Catalog # 0378

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

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Shipping Information

$35 to United States

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Key Product Details

Description:	Calmodulin antagonist
Chemical Name:	N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Molecular Weight:	433.44

View Full Technical Details for A-7 hydrochloride

Biological Activity

A-7 hydrochloride is a potent calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC₅₀ of 3 μM).

Technical Data

M. Wt	433.44
Formula	C₂₀H₂₉ClN₂O₂S.HCl
Storage	Store at RT
CAS Number	79127-24-5
PubChem ID	2735312
InChi Key	XDJCAQBTSCRBHS-UHFFFAOYSA-N
Smiles	Cl.NCCCCCCCCCCNS(=O)(=O)C1=C2C=CC=C(Cl)C2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.67	50

Preparing Stock Solutions

The following data is based on the product molecular weight 433.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.61 mL	23.07 mL	46.14 mL
2.5 mM	0.92 mL	4.61 mL	9.23 mL
5 mM	0.46 mL	2.31 mL	4.61 mL
25 mM	0.09 mL	0.46 mL	0.92 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Hidaka and Tanaka Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 1983 PMID: 6139736
Itoh and Hidaka Direct interaction of calmodulin antagonists with Ca²⁺/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 1984 PMID: 6099352