A-7 hydrochloride

Name: A-7 hydrochloride
Brand: tocris
SKU: 0378

Catalog # 0378

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	Calmodulin antagonist
Chemical Name:	N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

View Full Technical Details for A-7 hydrochloride

Technical Data
Citations / Reviews

Biological Activity

Potent calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC₅₀ of 3 μM).

Technical Data

M. Wt	433.44
Formula	C₂₀H₂₉ClN₂O₂S.HCl
Storage	Store at RT
CAS Number	79127-24-5
PubChem ID	2735312
InChi Key	XDJCAQBTSCRBHS-UHFFFAOYSA-N
Smiles	Cl.NCCCCCCCCCCNS(=O)(=O)C1=C2C=CC=C(Cl)C2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.67	50

Preparing Stock Solutions

The following data is based on the product molecular weight 433.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.61 mL	23.07 mL	46.14 mL
2.5 mM	0.92 mL	4.61 mL	9.23 mL
5 mM	0.46 mL	2.31 mL	4.61 mL
25 mM	0.09 mL	0.46 mL	0.92 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Hidaka and Tanaka Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 1983 PMID: 6139736
Itoh and Hidaka Direct interaction of calmodulin antagonists with Ca²⁺/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 1984 PMID: 6099352