4-DAMP
Tocris Bioscience, part of Bio-Techne | Catalog # 0482
Muscarinic M3 antagonist
Product Description
4-DAMP is an antagonist at the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors.Product Specifications
Molecular Weight
451.33
Formula
C21H26INO2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide
CAS Number
1952-15-4
PubChem ID
3014059
InChI Key
WWJHRSCUAQPFQO-UHFFFAOYSA-M
SMILES
[I-].C[N+]1(C)CCC(CC1)OC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.28 | 25 |
Preparing Stock Solutions
for 4-DAMP
The following data is based on the product molecular weight 451.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 8.86 mL | 44.31 mL | 88.63 mL |
| 1.25 mM | 1.77 mL | 8.86 mL | 17.73 mL |
| 2.5 mM | 0.89 mL | 4.43 mL | 8.86 mL |
| 12.5 mM | 0.18 mL | 0.89 mL | 1.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Michel Direct labelling of rat M3-muscarinic receptors by [3H]4-DAMP. Eur.J.Pharmacol. 1989 PMID: 2806372
- Barlow and Shepherd A further search for selective antagonists at M2- muscarinic receptors. Br.J.Pharmacol. 1986 PMID: 3814912
Product Specific Notices for 4-DAMP
For research use only
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