4-DAMP

Catalog # 0482

Citations (16)

COA / SDS

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Key Product Details

Description:	Muscarinic M₃ antagonist
Chemical Name:	1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide
Purity:	≥99% (HPLC)
Molecular Weight:	451.33

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Biological Activity

4-DAMP is an antagonist at the M₃ cholinergic receptor. [³H]-4-DAMP selectively labels M₁ and M₃ receptors.

Technical Data

M. Wt	451.33
Formula	C₂₁H₂₆INO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1952-15-4
PubChem ID	3014059
InChi Key	WWJHRSCUAQPFQO-UHFFFAOYSA-M
Smiles	[I-].C[N+]1(C)CCC(CC1)OC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.28	25

Preparing Stock Solutions

The following data is based on the product molecular weight 451.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.86 mL	44.31 mL	88.63 mL
1.25 mM	1.77 mL	8.86 mL	17.73 mL
2.5 mM	0.89 mL	4.43 mL	8.86 mL
12.5 mM	0.18 mL	0.89 mL	1.77 mL

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References

References are publications that support the biological activity of the product.

Michel Direct labelling of rat M₃-muscarinic receptors by [³H]4-DAMP. Eur.J.Pharmacol. 1989 PMID: 2806372
Barlow and Shepherd A further search for selective antagonists at M₂- muscarinic receptors. Br.J.Pharmacol. 1986 PMID: 3814912

Citations for 4-DAMP (16)

Showing 1 - 10 of 16 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for 4-DAMP include:

Emmerson et al. (2017) SOX2 regulates acinar cell development in the salivary gland. Elife. 6
PMID: 28623666
Wallace et al. (2015) Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine. Microvasc Res. 3
PMID: 26359240
Fonseca et al. (2015) Diadenosine tetraphosphate contributes to CB-induced tear secretion. Purinergic Signal. 11:87
PMID: 25398705
Mans et al. (2014) An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol. 112:2388
PMID: 25143547
Nedvetsky et al. (2014) Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 30:449
PMID: 25158854
Placeres-Uray et al. (2014) M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation. World Allergy Organ J. 6:22
PMID: 24377382
Pacini et al. (2014) M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther. 15:1489
PMID: 25482946
Jahchan et al. (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 3:1364
PMID: 24078773
Hodges et al. (2012) Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res. 103:99
PMID: 22975404
Kajiya et al. (2012) Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. J Neurosci. 82:115
PMID: 22511543
Chen et al. (2012) Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem. 287:5059
PMID: 22184108
Matsumoto et al. (2010) Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats. Urology. 75:862
PMID: 20156651
Kitazawa et al. (2009) M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. Mol Pharmacol. 330:487
PMID: 19429792
Clancy et al. (2007) Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. Physiol Rep. 27:6388
PMID: 17567799
Solanki et al. (2007) Cholinergic innervation of the guinea-pig isolated vas deferens. Naunyn Schmiedebergs Arch Pharmacol. 376:265
PMID: 17992517
Howell et al. (2005) In vivo antimuscarinic actions of the third generation antihistaminergic agent, deslorat. BMC Pharmacol. 5:13
PMID: 16109168

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