3-AQC

Name: 3-AQC
Brand: tocris
SKU: 0666

Catalog # 0666

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	5-HT₃ antagonist
Chemical Name:	3-(4-Allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate
Molecular Weight:	395.42

View Full Technical Details for 3-AQC

Biological Activity

A competitive 5-HT₃ antagonist, almost 100 times more potent than tropisetron, but with widely differing activity in various tissues.

Technical Data

M. Wt	395.42
Formula	C₁₆H₁₇N₅.C₄H₄O₄
Storage	Desiccate at -20°C
CAS Number	201216-42-4
PubChem ID	11567402
InChi Key	UHLVYEOCPBNJNA-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.C=CCN1CCN(CC1)C1=NC2=CC=CC=C2N=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.54	100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.64 mL	25.29 mL
5 mM	0.51 mL	2.53 mL	5.06 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Buznikov The pre-nervous serotonergic system of developing sea urchin embryos and larvae: pharmacologic and immunocytochemical evidence. Neurochem.Res. 2005 PMID: 16187217
Durk 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int.Immunol. 2005 PMID: 15802305
Monge Novel antagonists of 5-HT₃ receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives. J.Med.Chem. 1993 PMID: 8410988