Congo Red

Name: Congo Red
Brand: Tocris Bioscience
SKU: 5167

Tocris Bioscience, part of Bio-Techne | Catalog # 5167

COA / SDS

Amyloid fibril binding dye; also a VGlut inhibitor

Discontinued Product

5167 has been discontinued. View all Fluorescent Amyloid B Probes products.

Key Product Details

Description:	Amyloid fibril binding dye; also a VGlut inhibitor
Chemical Name:	3,3'-[(1,1'-Biphenyl)-4,4'-diyl-bis(2,1-diazenediyl)]bis(4-amino-1-naphthalenesulfonic acid) disodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	696.66

View Full Technical Details for Congo Red

Technical Data
Citations

Biological Activity for Congo Red

Congo Red is a VGlut inhibitor; decreases synaptic transmission in the dentate gyrus. Also an amyloid fibril-binding dye; inhibits Fib-beta A neurotoxicity by inhibiting fibril formation or by binding to preformed fibrils. Also inhibits the pancreatic islet cell toxicity of diabetes-associated amylin. Excitation wavelength is 497 nm.

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Technical Data for Congo Red

M. Wt	696.66
Formula	C₃₂H₂₂N₆Na₂O₆S₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	573-58-0
PubChem ID	11313
InChi Key	IQFVPQOLBLOTPF-UHFFFAOYSA-L
Smiles	NC2=C(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(N)C(C=CC=C6)=C6C(S(=O)(O[Na])=O)=C5)C=C4)C=C3)C=C(S(=O)(O[Na])=O)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Congo Red

References are publications that support the biological activity of the product.

Neale Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. 2013 PMID: 23303071
Neale Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortex. Neurochem.Int. 2013 PMID: 24121008
Lorenzo Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc.Natl.Acad.Sci.USA 1994 PMID: 7991613