Human TNF-beta/TNFSF1 Quantikine ELISA Kit

Name: Human TNF-beta/TNFSF1 Quantikine ELISA Kit
Brand: R&D Systems
SKU: DTB00

R&D Systems, part of Bio-Techne | Catalog # DTB00

Submit a review

Product Datasheet / COA

Discontinued Product

DTB00 has been discontinued. View all Lymphotoxin-alpha/TNF-beta products.

Key Product Details

Sensitivity:	7 pg/mL
Assay Range:	31.2 - 2,000 pg/mL

View all Lymphotoxin-alpha/TNF-beta ELISA Kits »

View Full Technical Details for Human TNF-beta/TNFSF1 Quantikine ELISA Kit

Technical Data
Citations / Reviews

Product Specifications for Human TNF-beta/TNFSF1 Quantikine ELISA Kit

Measurement	Quantitative ELISA
Detection Method	Colorimetric - 450nm (TMB)
Conjugate	Unconjugated
Reactivity	Human
Cross-reactivity	< 0.5% cross-reactivity observed with available related molecules. < 50% cross-species reactivity observed with species tested.
Interference	No significant interference observed with available related molecules.

Preparation and Storage

Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Lymphotoxin-alpha/TNF-beta

Lymphotoxin alpha and Lymphotoxin beta are pro-inflammatory TNF superfamily ligands that play important roles in immune system development. LT-alpha can be secreted as a homotrimer that binds and activates TNF RI, TNF RII, HVEM, and TROY. It is required for development of the spleen, lymph nodes, and Peyer’s patches. It also regulates T cell homing to the gut and IgA induction. LT-alpha can additionally form membrane-associated heterotrimers with two copies of LT-beta/TNF-beta on the surface of B, T, LTi, and ILC3 cells. This heterotrimer binds and activates the Lymphotoxin beta R on macrophages, dendritic cells, hepatocytes, intestinal epithelial cells (IEC), follicular dendritic cells (FDC), and high endothelial venules (HEV). The heterotrimer promotes the development of FDC networks and HEV in lymphoid tissue, the class switching of immature B cells for IgA production, and the production of homeostatic IL-22 by IEC.

Item	Value
Long Name	Tumor Necrosis Factor beta
Entrez Gene IDs	4049 (Human); 16992 (Mouse)
Alternate Names	LT, LT-alpha, LTA, Lymphotoxin alpha, Lymphotoxin-alpha, Lymphotoxinalpha, TNF-beta, TNFBlymphotoxin-alpha, TNFSF1, TNFSF1B, TNFSF1TNF-beta, Tumor necrosis factor ligand superfamily member 1, lymphotoxin alpha (TNF superfamily, member 1), tnfb, tumor necrosis factor beta

Customer Reviews for Human TNF-beta/TNFSF1 Quantikine ELISA Kit

There are currently no reviews for this product. Be the first to review Human TNF-beta/TNFSF1 Quantikine ELISA Kit and earn rewards!

Have you used Human TNF-beta/TNFSF1 Quantikine ELISA Kit?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review

Product Documents for Human TNF-beta/TNFSF1 Quantikine ELISA Kit

Product Datasheets

Download Product Datasheets