Cultrex Human Fibronectin, PathClear

Cultrex Human Fibronectin, Pathclear is purified from human plasma and is Pathclear certified to be free of common pathogens. Fibronectin is an extracellular matrix protein that is found abundantly in blood and connective tissues. These matrices are associated with the epithelial to mesenchymal transition of metastatic cells--including tumor cells with stem cell-like properties. Fibronectin performs essential functions in collagen fibrillogenesis, as either a general cell adhesion molecule or a modulator in binding between cell surfaces and the extracellular matrix. Fibronectin matrix assembly is essential for normal vertebrate development and apparently contributes to the generation of tumor metastases by supporting the establishment and persistence of pre-metastatic niches. Fibronectin is secreted as a disulfide-linked dimer of 230-270 kDa, comprised of three types of repeating modules that mediate interactions with extracellular matrix components (including fibronectin itself), and cells via integrins and other fibronectin receptors. Thus, fibronectin can be used for coating tissue culture surfaces or as a medium additive to promote cell adhesion and proliferation; it is 0.2 μm sterile filtered.