Biotin(Terminal)-PAR
R&D Systems, part of Bio-Techne | Catalog # 4336-100-02
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Species Reactivity
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Background: PAR/pADPr
PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.
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Product Documents for Biotin(Terminal)-PAR
Product Specific Notices for Biotin(Terminal)-PAR
For research use only