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Angiotensin I Antibody (BGN/KA/4H) [DyLight 755]

Novus Biologicals, part of Bio-Techne | Catalog # NB100-62344IR

Novus Biologicals, part of Bio-Techne
Discontinued Product
NB100-62344IR has been discontinued. View all Angiotensin I products.

Key Product Details

Species Reactivity

Human, Rat

Applications

Western Blot, ELISA

Label

DyLight 755 (Excitation = 754 nm, Emission = 776 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # BGN/KA/4H

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acids 40-49 of the angiotensinogen precursor (Swiss-Prot entry P01019) conjugated to HMW carrier protein.

Epitope

P-F-H-L-V-I-H-N-E-S(-C)

Reactivity Notes

Use in Rat reported in scientific literature (PMID:33028854).

Specificity

NB100-62344 is specific for Angiotensin I and does not react with angiotensin II, III or angiotensinogen in ELISA. Enzyme (ACE) into a vasoactive form called Angiotensin II which is responsible for increasing blood pressure. Angiotensin I is important in the Renin-Angiotensin-Aldosterone System (RAAS). RAAS is responsible for the regulation of blood pressure and water retention in the body. Angiotensin I is produced from a reaction between the renal enzyme Renin and angiotensinogen. It is converted by Angiotensin Converting Enzyme (ACE) into a vasoactive form called Angiotensin II which is responsible for increasing blood pressure.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Description

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Applications for Angiotensin I Antibody (BGN/KA/4H) [DyLight 755]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Angiotensin I

The protein encoded by the Angiotensin I gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.

Alternate Names

alpha-1 antiproteinase, antitrypsin, angiotensin II, angiotensinogen, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), ANHU, FLJ92595, FLJ97926, pre-angiotensinogen, serine (or cysteine) proteinase inhibitor, Serpin A8, SERPINA8angiotensin I

Gene Symbol

AGT

Additional Angiotensin I Products

Product Documents for Angiotensin I Antibody (BGN/KA/4H) [DyLight 755]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Angiotensin I Antibody (BGN/KA/4H) [DyLight 755]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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