CE-SDS delivers the same size-based protein separation as SDS-PAGE—without the manual mess. In this application note, see how the Maurice system with Turbo CE-SDS cartridge brings speed, precision, and reproducibility to protein characterization. Real-world comparisons with SDS-PAGE highlight why CE-SDS is the better fit for today’s analytical needs.

This application note details capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) analysis for two AAV CQAs - identity and purity. Instead of using SDS-PAGE for AAV purity and confirming serotypes using PCR or ELISA, you can get data on different attributes of your samples with one platform. 

This application note provides a comparability study using the Maurice CE-SDS PLUS method with the USP <129> protocol for the analysis of monoclonal antibodies. Using USP’s IgG System Suitability Reference Standard, the USP <129> method was first run on Maurice to determine ease of method transfer, followed by optimization of the Maurice protocol for comparison with USP <129>.

This application note demonstrates a rapid, high-quality CE-SDS method on the Maurice system for the analysis of IgM proteins. Specifically, you will read about how the Turbo CE-SDS cartridge provides data on IgM purity, stability, identity, and reproducibility, in just 14 minutes of run time. 

This whitepaper describes how the Maurice instrument, using the Turbo CE-SDS cartridge, provides quantitative data that can be used for the analysis of purity of cell culture samples for both the supernatants as well as the purified antibodies. This workflow offers a fast method to screen a high volume of upstream samples during the cell culture and cell line development stages.

This application note demonstrates a robust and automated CE-SDS method on the Maurice instrument, which can be used as both an identity assay as well as a titer assay for LVV analysis using the Maurice CE-SDS PLUS method. The advantages versus using ELISA and SDS-PAGE methods are discussed.