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Targeted Protein Degradation (TPD) is a simple and versatile method to knock-down a target protein of interest using small molecules (including PROTAC® Degraders, SNIPERS, molecular glues etc.) and is an area of increasing research interest. The PROTAC® Degraders approach employs bifunctional small molecules, which simultaneously bind to the target protein of interest and an E3 ligase to form a ternary complex. This initiates the ubiquitination of the target protein and its subsequent destruction by the proteasome. Using this technology, efficient and highly selective protein knock-down can be achieved both in vitro and in vivo. This brochure highlights the tools and services available from Bio-Techne to support your TPD research, including:

  • Active Degraders
  • Degrader Building Blocks
  • PROTAC® Panel Builder
  • TAG Degradation Platform
  • Ubiquitin Proteasome System Proteins
  • Assays for Targeted Protein Degradation

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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license