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13 results for "CHRM4 Small Molecules and Peptides" in Products

CHRM4: Small Molecules and Peptides

Muscarinic acetylcholine receptor M4 is an Acetylcholine Receptor. Unlike muscarinic receptor M2, the M4 receptor is not involved in smooth muscle contraction. The clinical relevance of this receptor is unknown. However, mouse studies have linked it to adenylyl cyclase inhibition. Muscarinic acetylcholine receptor M4 has been reported to be expressed in many regions of the rat brain, particularly the striatum and hippocampus. ESTs have been isolated from human breast and eye libraries.

Selective M2 antagonist

Alternate Names: Otenzepad
Chemical Name: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Purity: ≥98% (HPLC)
Selective M2 antagonist

Functionally biased muscarinic M4 receptor agonist

Chemical Name: 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate
Purity: ≥98% (HPLC)
Functionally biased muscarinic M4 receptor agonist

Muscarinic agonist

Chemical Name: (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone hydrochloride
Purity: ≥98% (HPLC)
Muscarinic agonist

Muscarinic agonist

Chemical Name: 1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinone sesquifumarate
Purity: ≥98% (HPLC)
Muscarinic agonist

Positive allosteric modulator of M4 receptors

Alternate Names: ML 108
Chemical Name: 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide
Purity: ≥98% (HPLC)
Positive allosteric modulator of M4 receptors

Potent M2/M4 antagonist

Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Purity: ≥98% (HPLC)
Potent M2/M4 antagonist

Potent and selective M4 mAChR antagonist

Chemical Name: (3aR,5s,6aS)-2-((Tetrahydro-2H-pyran-4-yl)methyl)-N-(6-(2,3,5-trifluorophenyl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine hydrochloride
Purity: ≥98% (HPLC)
Potent and selective M4 mAChR antagonist

Selective M1 muscarinic agonist

Chemical Name: 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride
Purity: ≥99% (HPLC)
Selective M1 muscarinic agonist

Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic

Chemical Name: 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic

Selective M4 antagonist

Chemical Name: 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester
Purity: ≥98% (HPLC)
Selective M4 antagonist

Selective positive allosteric modulator of M4 receptors

Chemical Name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Selective positive allosteric modulator of M4 receptors

Positive allosteric modulator of M2 and M4 receptors

Chemical Name: 3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Positive allosteric modulator of M2 and M4 receptors

High affinity and selective M2 antagonist

Chemical Name: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Purity: ≥98% (HPLC)
High affinity and selective M2 antagonist
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