AQ-RA 741
Tocris Bioscience, part of Bio-Techne | Catalog # 2292
High affinity and selective M2 antagonist
Key Product Details
Description
High affinity and selective M2 antagonist
Product Description
AQ-RA 741 is a high affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). Displays cardioselectivity in vivo, over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.Product Specifications
Molecular Weight
463.62
Formula
C27H37N5O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
CAS Number
123548-16-3
PubChem ID
129989
InChI Key
BCUGCHZRMKTPMU-UHFFFAOYSA-N
SMILES
CCN(CC)CCCCC1CCN(CC(=O)N2C3=CC=CC=C3C(=O)NC3=C2N=CC=C3)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 46.36 | 100 | |
| DMSO | 46.36 | 100 | |
| Ethanol | 46.36 | 100 |
Preparing Stock Solutions
for AQ-RA 741
The following data is based on the product molecular weight 463.62
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.16 mL | 10.78 mL | 21.57 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.31 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dorje Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J.Pharmacol.Exp.Ther. 1991 PMID: 1994002
- Doods Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur.J.Pharmacol. 1994 PMID: 8200421
- Doods Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug. Eur.J.Pharmacol. 1991 PMID: 2040358
Product Specific Notices for AQ-RA 741
For research use only
Loading...
Loading...