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• High Levels of Biological Activity: The biological activity of each protein is tested in an appropriate biological system to confirm that it meets our strict QC activity parameters before it is released to market.

• Lot-to-Lot Consistency: Minimal lot-to-lot variability is ensured by maintaining consistent manufacturing conditions and testing each new lot side-by-side with previous lots and with a master lot, so you don’t have to worry whether results will be reproducible over time.

• High Purity: The majority of our proteins have >95% purity and a guaranteed industry-leading endotoxin level of <0.1 EU/ug by the LAL method.

• Long-term Stability: The bioactivity and physical state of our proteins are monitored through multiple freeze/thaw cycles, so you can be confident that your protein will be stable over long periods of time. All proteins are shipped lyophilized or in specially optimized formulations to ensure that they reach you in perfect condition.

• Comprehensive Selection: Our catalog includes over 5,000 biologically active recombinant and natural proteins spanning 35 species, and more than 10,000 non-catalog proteins for multiple different research areas, allowing you to easily find the proteins that you need.

• Multiple Host Expression Systems, Tags, and Labels: Our proteins are produced in a variety of host expression systems and are either untagged or include a biotin, Fc, or His tag, or a fluorescent label to meet different experimental needs.

• Seamless Transition from RUO to GMP: Our Animal-free and GMP-grade proteins frequently originate from the same clone, sequence, and expression system as our traditional research-grade proteins, making the transition from basic research into process development and clinical manufacturing as efficient and seamless as possible.

• Bulk Proteins at Discounted Prices: We have the capacity and the expertise to scale up the production of any protein and we offer economical pricing on bulk orders.

• Custom Protein Capabilities: If you don’t see the protein that you need on our website, we offer custom protein services. From scratch protein development to customizing a protein from our catalog, our custom services team will work with you to create the product that fits your experimental needs.

• Custom Bottling Options: If your research requires a special formulation or size, custom bottling options are available.

• Expert Customer Support Assistance: Almost all of our proteins are manufactured in-house, allowing us to maintain complete control over the quality of our products. If you have any questions about our products, our protein scientists and highly trained technical service team are always available to assist you.

R&D Systems Recombinant Human FGF basic/FGF-2 Displays Higher Activity than a Leading Competitor’s Recombinant Human FGF-2 Protein. The NR6R-3T3 mouse fibroblast cell line was treated with increasing concentrations of R&D Systems Recombinant Human FGF basic/FGF-2 (Catalog # 233-FB; orange line) or recombinant human FGF-2 from another company (blue line) and cell proliferation was assessed. The bioactivity of the R&D Systems FGF-2 protein was approximately 3-fold greater than the leading competitor’s FGF-2 protein. 

R&D Systems Recombinant Human Wnt-3a Protein Displays Higher Activity than a Leading Competitor’s Recombinant Wnt-3a. The bioactivity of R&D Systems Recombinant Human Wnt-3a (Catalog # 5036-WN; orange line) or recombinant human Wnt-3a from another company (green line) was assessed by measuring the ability of the proteins to induce alkaline phosphatase production in the MC3T3-E1 mouse preosteoblast cell line. The ED₅₀ of R&D Systems Recombinant Human Wnt-3a was 1.7-fold better than the leading competitor’s Wnt-3a protein, with more than twice the maximum response.

R&D Systems Recombinant Human GDNF Displays Higher Activity than a Leading Competitor’s Recombinant Human GDNF Protein. The bioactivity of R&D Systems Recombinant Human GDNF (Catalog # 212-GD; orange line) or recombinant human GDNF from another company (blue line) was assessed by measuring the ability of the proteins to stimulate the proliferation of SH-SY5Y human neuroblastoma cells, in the presence of Recombinant Human GFR alpha-1 (R&D Systems, Catalog # 714-GR). The activity of the R&D Systems GDNF protein was approximately 9-fold greater than the leading competitor’s GDNF protein.

Lot-to-Lot Consistency Testing of Recombinant Human SCF/c-kit Ligand. Two independent lots of Recombinant Human SCF/c-kit Ligand (R&D Systems, Catalog # 11010-SC) were tested for their ability to stimulate the proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 1-5 ng/mL. Each trace on the graph represents Recombinant Human SCF/c-kit Ligand from a different manufacturing run, demonstrating the lot-to-lot consistency of the protein.

Lot-to-Lot Consistency Testing of Recombinant Human Flt-3 Ligand. Two independent lots of Recombinant Human Flt-3 Ligand (R&D Systems, Catalog # 308-FKE) were tested for their ability to stimulate the proliferation of BaF3 mouse pro-B cells transfected with mouse Flt-3. The ED₅₀ for this effect is 0.2-1 ng/mL. Each trace on the graph represents Recombinant Human Flt-3 Ligand from a different manufacturing run, demonstrating the lot-to-lot consistency of the protein.

Lot-to-Lot Consistency Testing of Recombinant Human FGF basic/FGF2. Two independent lots of Recombinant Human FGF basic (R&D Systems, Catalog # 233-FB) were tested for their ability to stimulate the proliferation of NR6R-3T3 mouse fibroblast cells. The ED₅₀ for this effect is 0.1-0.6 ng/mL. Each trace on the graph represents Recombinant Human FGF basic from a different manufacturing run, demonstrating the lot-to-lot consistency of the protein.