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iCE™ 平台可执行成像毛细管等电聚焦 (cIEF) 和十二烷基硫酸钠毛细管电泳 (CE-SDS),对您的治疗性蛋白质进行鉴别、纯度和异质性分析,且分析可重现、可量化。而且分析速度非常快——每个样本只需 15 分钟或更短时间即可获得结果!您还将获得高分辨率,享受全自动化流程,而不必担心其他 IEF 技术存在的各种麻烦。Maurice 平台还可自动化完成按大小分离,因此,您也可以对单克隆抗体进行可靠的定量分析。

用于 cIEF 和 CE-SDS 的 iCE 仪器

Maurice​ One-stop cIEF and CE-SDS​ Purity, identity, and heterogeneity analysis​

Maurice

一站式 cIEF 和 CE-SDS

纯度、鉴别和异质性分析

Maurice S.​ Ready-to-go CE-SDS or CE-SDS PLUS​ Simplifies size separation workflows​

Maurice S。

即用型 CE-SDS 或 CE-SDS PLUS

简化按大小分离工作流程

cIEF and CE-SDS with iCE

Maurice C。

快速获取 cIEF 数据

鉴别和电荷异质性

iCE3​ Current standard for cIEF protein charge heterogeneity analysis​

iCE3

cIEF 蛋白质电荷异质性分析的现行标准

哪种成像 cIEF/CE-SDS 系统适合您?

* 使用 Alcott 自动进样器

系统

Maurice

Maurice C。

Maurice S。

iCE3

cIEF 应用(按电荷分离)

CE-SDS 应用(按大小分离)

吸光度检测

荧光检测

样本制备机上混合

是*

说明

cIEF 技术规格

CE-SDS 技术规格

最小样本量

50 µL

50 µL

样本输送

真空

电动力学

典型分离时间

6-10 分钟(因分子而异)

220 nm 下的紫外吸光度

检测能力

预聚焦:1500 V,聚焦:3000 V

分离:5750 V

每个试剂卡盒的进样次数

保证 100 次,最多 200 次

保证 100 次,CE-SDS 最多 200 次,CE-SDS PLUS 最多 500 次

每批最多进样次数

100

48

pI/大小范围

2.85-10.45

10-270 kDa

pI/大小分析 CV

1%

≤2%

峰面积 >10% 组份的 CV

≤5%(批内),≤6%(批间)

不适用

pI/大小分辨率

2 个 log

2 个 log

动态范围

2 个 log

2 个 log

线性度

>0.995

>0.995

灵敏度 (LOD)

0.7 µg/mL(天然荧光) 3.0 µg/mL(吸光度)(基于单克隆抗体获得的值)

0.3 µg/mL (基于内标获得的值)

样本盘选项

96 孔板或 48 瓶

96 孔板或 48 瓶

功率

100 V-240 V (AC),50/60 Hz,500 W

100 V-240 V (AC),50/60 Hz,500 W

温度控制范围

4-25℃

4-25℃

尺寸

44 cm 高 x 42 cm 宽 x 61 cm 深

44 cm 高 x 42 cm 宽 x 61 cm 深

重量

46 千克(100 磅)

46 千克(100 磅)

iCE Applications

Bioprocessing

Bioprocessing

Whether it is during clone selection or final product characterization, use a hassle-free, robust, and fast method to characterize the charge and size profiles of your therapeutic.

CE-SDS

CE-SDS

Get automated, reproducible, and high-throughput CE-SDS analysis in as little as 25 minutes per sample.

Cell & Gene Therapy

Cell & Gene Therapy

Next-generation analytical instrumentation to help improve and accelerate your cell and gene therapy workflows.

Protein Charge Heterogeneity

Protein Charge Heterogeneity

High-quality absorbance and native fluorescence give you charge heterogeneity data for even the most complex proteins with automated, whole-column cIEF.

Protein Stability and Formulation Testing

Protein Stability and Formulation Testing

Understand the impact of protein changes on drug safety and efficacy and develop the best formulation for your therapeutic with cIEF analysis.

Protein and Antibody Characterization

Protein & Antibody Characterization

Rapidly and accurately monitor the charge and molecular weight heterogeneity of your proteins, two critical properties that inevitably change during development.

Post-translation Modification

Post-translation Modification

To know if your proteins have undergone deamidation, oxidation, glycation, or another other post-translational modification, get accurate data on their changing isoelectric points.

Biosimilars

Biosimilars

Gain confidence in your biosimilars by getting accurate, high-quality data on the charge and size profiles of your proteins and antibodies.

Vaccine

Vaccine Development

Whether you’re working with LNPs or viral vectors, confirm their charge heterogeneity, identity, and purity, and proceed confidently with your vaccine development.

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