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用于 cIEF 和 CE-SDS 的 iCE 仪器
哪种成像 cIEF/CE-SDS 系统适合您？
|
系统 |
Maurice |
Maurice C。 |
Maurice S。 |
iCE3 |
|---|---|---|---|---|
|
cIEF 应用（按电荷分离） |
是 |
是 |
否 |
是 |
|
CE-SDS 应用（按大小分离） |
是 |
否 |
是 |
否 |
|
吸光度检测 |
是 |
是 |
是 |
是 |
|
荧光检测 |
是 |
是 |
否 |
否 |
|
样本制备机上混合 |
是 |
是 |
否 |
是* |
|
说明 |
cIEF 技术规格 |
CE-SDS 技术规格 |
|---|---|---|
|
最小样本量 |
50 µL |
50 µL |
|
样本输送 |
真空 |
电动力学 |
|
典型分离时间 |
6-10 分钟（因分子而异） |
220 nm 下的紫外吸光度 |
|
检测能力 |
预聚焦：1500 V，聚焦：3000 V |
分离：5750 V |
|
每个试剂卡盒的进样次数 |
保证 100 次，最多 200 次 |
保证 100 次，CE-SDS 最多 200 次，CE-SDS PLUS 最多 500 次 |
|
每批最多进样次数 |
100 |
48 |
|
pI/大小范围 |
2.85-10.45 |
10-270 kDa |
|
pI/大小分析 CV |
1% |
≤2% |
|
峰面积 >10% 组份的 CV |
≤5%（批内），≤6%（批间） |
不适用 |
|
pI/大小分辨率 |
2 个 log |
2 个 log |
|
动态范围 |
2 个 log |
2 个 log |
|
线性度 |
>0.995 |
>0.995 |
|
灵敏度 (LOD) |
0.7 µg/mL（天然荧光） 3.0 µg/mL（吸光度）（基于单克隆抗体获得的值） |
0.3 µg/mL （基于内标获得的值） |
|
样本盘选项 |
96 孔板或 48 瓶 |
96 孔板或 48 瓶 |
|
功率 |
100 V-240 V (AC)，50/60 Hz，500 W |
100 V-240 V (AC)，50/60 Hz，500 W |
|
温度控制范围 |
4-25℃ |
4-25℃ |
|
尺寸 |
44 cm 高 x 42 cm 宽 x 61 cm 深 |
44 cm 高 x 42 cm 宽 x 61 cm 深 |
|
重量 |
46 千克（100 磅） |
46 千克（100 磅） |
iCE Applications
Bioprocessing
Whether it is during clone selection or final product characterization, use a hassle-free, robust, and fast method to characterize the charge and size profiles of your therapeutic.
CE-SDS
Get automated, reproducible, and high-throughput CE-SDS analysis in as little as 25 minutes per sample.
Cell & Gene Therapy
Next-generation analytical instrumentation to help improve and accelerate your cell and gene therapy workflows.
Protein Charge Heterogeneity
Protein Charge Heterogeneity
High-quality absorbance and native fluorescence give you charge heterogeneity data for even the most complex proteins with automated, whole-column cIEF.
Protein Stability and Formulation Testing
Protein Stability and Formulation Testing
Understand the impact of protein changes on drug safety and efficacy and develop the best formulation for your therapeutic with cIEF analysis.
Protein & Antibody Characterization
Protein & Antibody Characterization
Rapidly and accurately monitor the charge and molecular weight heterogeneity of your proteins, two critical properties that inevitably change during development.
Post-translation Modification
Post-translation Modification
To know if your proteins have undergone deamidation, oxidation, glycation, or another other post-translational modification, get accurate data on their changing isoelectric points.
Biosimilars
Biosimilars
Gain confidence in your biosimilars by getting accurate, high-quality data on the charge and size profiles of your proteins and antibodies.
Vaccine Development
Vaccine Development
Whether you’re working with LNPs or viral vectors, confirm their charge heterogeneity, identity, and purity, and proceed confidently with your vaccine development.
