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Maurice: One Instrument for CE-SDS and cIEF

Meet Maurice

Maurice from Protein Simple, a Bio-Techne Brand

Maurice is the all-in-one capillary electrophoresis instrument built on iCE technology that lets you:

  • Analyze proteins for charge (icIEF) and molecular weight (CE-SDS)
  • Save time with same-day method development
  • Simplify science through automation
  • Save your samples because of higher instrument sensitivity
  • Get data you can trust through reproducibility and quality
  • Stay compliant with industry-validated software

Hear from Maurice Users

How are scientists in the biopharmaceutical industry using the Maurice system for protein charge and size analysis? Check out these videos featuring scientists who have used Maurice for method transfer, formulation, and gene therapy development. They share their experiences and insights on using Maurice for different applications to do cutting-edge biotherapeutic development.

Hear from iCE Maurice Users
Protein Charge Antibody

Protein Charge Analysis with icIEF

Reproducible charge heterogeneity analysis under 10 minutes with whole-column imaging using Maurice or Maurice C.

Looking for iCE3? Visit us here.

Protein Analysis Antibody

Protein Size Analysis with CE-SDS

Automated and highly quantitative analysis of protein purity in as little as 5.5 minutes with Maurice or Maurice S.

three vials representing icIEF-based protein fractionation

icIEF-based Protein Fractionation

Same-day charge heterogeneity analysis and charge variant fractionation on MauriceFlex.

iCE3 to Maurice - ProteinSimple iCE systems iCE3, iCE280, and Maurice

Switch from iCE3 to Maurice

Maurice does everything that your iCE3 does, only faster and easier.

maurice consumables

iCE Consumables

You can now order consumables for Maurice and iCE online.

Maurice Cartridge Turbo CE-SDS

CE-SDS Just Got 5x Faster

With Turbo CE-SDS get high-quality size analysis in as little as 5.5 minutes for high-throughput applications.

Imaged Capillary Electrophoresis (iCE) Applications

innovations in bioprocess workflow solutions

Bioprocessing

Whether it is during clone selection or final product characterization, use a hassle-free, robust, and fast method to characterize the charge and size profiles of your therapeutic.

tools for cell and gene therapy

Cell & Gene Therapy

Next-generation analytical instrumentation to help improve and accelerate your cell and gene therapy workflows.

tools for biosimilar development

Biosimilars

Gain confidence in your biosimilars by getting accurate, high-quality data on the charge and size profiles of your proteins and antibodies.

accelerate your vaccine development

Vaccine Development

Whether you’re working with LNPs or viral vectors, confirm their charge heterogeneity, identity, and purity, and proceed confidently with your vaccine development.

Maurice 虚拟演示

来探索一下,看看使用 Maurice 测定电荷和大小异质性有多容易。

ProteinSimple Maurice Demo Intro

哪款 Maurice 适合您?

 

系统

Maurice

Maurice C.

Maurice S.

MauriceFlex

icIEF 应用(按电荷分离)

CE-SDS 应用(按大小分离)

icIEF 组分收集

紫外吸收检测

自发荧光检测

在线预混(OBM)

技术规格

说明

cIEF

CE-SDS PLUS

Turbo CE-SDS

cIEF 分离

最小样本量

50 µL

50 µL

100 µL

100 µL

进样方式

真空

电动

电动

真空

典型分离时间

6-10 分钟(因分子而异)

还原的 IgG:25 分钟;非还原 IgG:35 分钟

还原的 IgG:5.5 分钟;非还原 IgG:8 分钟

40 - 50 分钟(因分子而异)
检测方式 280 nm 下的紫外吸光度

荧光:激发波长 (Ex) 280 nm,发射波长 (Em) 320-450 nm
220 nm 下的紫外吸光度 220 nm 下的紫外吸光度 荧光:激发波长 (Ex) 280 nm,发射波长 (Em) 320-450 nm

典型电压

预聚焦:1500 V
聚焦:3000 V

分离:5750 V

分离:4200 V

预聚焦:500 V 和 1000 V
聚焦:1500 V

每个卡盒的进样针数

保证 100 次,最多 200 次(最多 25 个批次)

保证 100 次,最多 500 次(最多 25 个批次)

保证 100 次(最多 25 个批次)

最多 15 次进样

每个序列最大进样针数

100

48

96

1(分离)
4 (cIEF)
 

pI/大小范围

2.85-10.45

10-270 kDa

10-270 kDa

3-10

pI/大小分析 CV

1%

≤2%

<2%

1%

峰面积 >10% 组分的 CV

≤5%(批内),≤6%(批间)

不适用

不适用

≤10%(批间)
相对迁移时间 CV 不适用 还原的 IgG <1% <5% 不适用

pI/大小分辨率

0.05 个 pl 单位(宽范围 3-10 两性电解质)

≥ 1.5(NGHC/HC IgG 标准品)

≥ 1.0(NGHC/HC IgG 标准品)

不适用

动态范围

2 个数量级

2 个数量级

2 个数量级

不适用

线性

>0.995

>0.995

>0.995

不适用

灵敏度 (LOD)

0.7 µg/mL(天然荧光)
3.0 µg/mL(吸光度)(基于单克隆抗体获得的值)

0.3 µg/mL
(基于内标获得的值)

0.6 μg/mL(基于内标获得的值)

不适用

样本盘选择

96 孔板或 48 样品管

96 孔板或 48 样品管

96 孔板或 48 样品管

仅 96 孔板

功率

100 V-240 V (AC),50/60 Hz,500 W

100 V-240 V (AC),50/60 Hz,500 W

100 V-240 V (AC),50/60 Hz,500 W

100 V-240 V (AC),50/60 Hz,500 W
电压范围 0–6,500 V 0–6,500 V 0–6,500 V 0–6,500 V

温度控制范围

4-25℃

4-25℃

4-25℃

10-25℃

大小尺寸

44 cm 高 x 42 cm 宽 x 61 cm 深

44 cm 高 x 42 cm 宽 x 61 cm 深

44 cm 高 x 42 cm 宽 x 61 cm 深

44 cm 高 x 42 cm 宽 x 61 cm 深

重量

46 千克(100 磅)

46 千克(100 磅)

46 千克(100 磅)

46 千克(100 磅)
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