VU 152100
Tocris Bioscience, part of Bio-Techne | Catalog # 3383
Positive allosteric modulator of M4 receptors
Key Product Details
Description
Positive allosteric modulator of M4 receptors
Alternative Names
ML 108
Product Description
VU 152100 is a selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM). Induces 21-fold shift in ACh potency at M4 receptor. Displays no activity at other mAChR subtypes.Product Specifications
Molecular Weight
341.43
Formula
C18H19N3O2S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide
CAS Number
409351-28-6
PubChem ID
864492
InChI Key
MDNWGCQSCGNTKH-UHFFFAOYSA-N
SMILES
CC1=C2C(SC(C(NCC3=CC=C(OC)C=C3)=O)=C2N)=NC(C)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.07 | 50 |
Preparing Stock Solutions
for VU 152100
The following data is based on the product molecular weight 341.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.86 mL | 29.29 mL | 58.58 mL |
| 2.5 mM | 1.17 mL | 5.86 mL | 11.72 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
| 25 mM | 0.12 mL | 0.59 mL | 1.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brady Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 2008 PMID: 18772318
Product Specific Notices for VU 152100
For research use only
Loading...
Loading...