VU 10010

Name: VU 10010
Brand: Tocris Bioscience
SKU: 3141
Price: 228 USD

Catalog # 3141 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Selective positive allosteric modulator of M4 receptors

Key Product Details

Description:	Selective positive allosteric modulator of M₄ receptors
Chemical Name:	3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	345.85

View Full Technical Details for VU 10010

Biological Activity for VU 10010

VU 10010 is a selective allosteric potentiator of M₄ acetylcholine receptors (EC₅₀ values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.

Technical Data for VU 10010

M. Wt	345.85
Formula	C₁₇H₁₆ClN₃OS
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	633283-39-3
PubChem ID	714286
InChi Key	FPRULFHDSFKYBV-UHFFFAOYSA-N
Smiles	CC1=C2C(SC(C(NCC3=CC=C(Cl)C=C3)=O)=C2N)=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 10010

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.59	100
	ethanol	3.46	10

Preparing Stock Solutions for VU 10010

The following data is based on the product molecular weight 345.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.46 mL	28.91 mL
5 mM	0.58 mL	2.89 mL	5.78 mL
10 mM	0.29 mL	1.45 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for VU 10010

References are publications that support the biological activity of the product.

Shirey An allosteric potentiator of M₄ mAChR modulates hippocampal synaptic transmission. Nat.Chem.Biol. 2008 PMID: 18059262

Citations for VU 10010 (1)

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Citations are publications that use Bio-Techne products. Selected citations for VU 10010 include:

Bell et al. (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. PLoS One. 9:115
PMID: 25918499

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Product Documents for VU 10010

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.