Active Degraders Products

dTAG^V-1

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Chemical Name:	(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate trifluoroacetate
Purity:	≥98% (HPLC)

dTAG-13

Catalog #: 6605

Citations (136)

Product Documents

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name:	1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity:	≥98% (HPLC)

BromoTag^® AGB1

Catalog #: 7686

Citations (12)

Product Documents

Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

Chemical Name:	(S)-13-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoate
Purity:	≥98% (HPLC)

dTAG^V-1 hydrochloride

Catalog #: 7374

Citations (3)

Product Documents

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

Chemical Name:	(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride
Purity:	≥98% (HPLC)

aTAG 4531

Catalog #: 6971

Citations (1)

Product Documents

Degrader of MTH1 fusion proteins for use within the aTAG system

Alternate Names:	CFT 4531
Chemical Name:	N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
Purity:	≥98% (HPLC)

SNIPER(ER)-87

Catalog #: 7120

Citations (1)

Product Documents

Potent and selective ERα Degrader (SNIPER)

Chemical Name:	(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
Purity:	≥98% (HPLC)

α-Synuclein Degrader 2b

Catalog #: 8040

Citations (1)

Product Documents

α-synuclein Degrader (PROTAC®)

Chemical Name:	2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
Purity:	≥98% (HPLC)

dBET6

Catalog #: 6945

Citations (8)

Product Documents

Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Chemical Name:	(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:	≥98% (HPLC)

NR 7h

Catalog #: 7177

Citations (1)

Product Documents

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo

Chemical Name:	3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(4-(1-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide
Purity:	≥97% (HPLC)

dBET1

Catalog #: 6327

Citations (3)

Product Documents

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Chemical Name:	(6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:	≥98% (HPLC)

ZNL 02-096

Catalog #: 7240

Citations (2)

Product Documents

Potent and selective Wee1 Degrader (PROTAC®)

Chemical Name:	4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity:	≥98% (HPLC)

MC 1 New

Catalog #: 8843

Product Documents

Selective EP300 Degrader (PROTAC®)

Chemical Name:	(2S,4R)-1-((S)-2-(8-(2-(4-(6-((R)-2-(((S)-2-(4-Cyanophenyl)propyl)amino)-2-phenylacetamido)pyridin-3-yl)-1H-pyrazol-1-yl)acetamido)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)

dTAG-47

Catalog #: 7530

Citations (4)

Product Documents

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name:	(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity:	≥97% (HPLC)

MS 147

Catalog #: 8077

Product Documents

PRC1 Degrader (PROTAC®); degrades BMI1 and RING1B

Chemical Name:	(2S,4R)-1-((S)-2-(7-(5-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)pentanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Purity:	≥97% (HPLC)

SJFδ

Catalog #: 7267

Product Documents

Potent and selective p38δ PROTAC®

Chemical Name:	N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Purity:	≥98% (HPLC)

HER2 PROTAC^® CH7C4

Catalog #: 7886

Citations (1)

Product Documents

Potent and selective HER2 targeting Degrader (PROTAC®)

Chemical Name:	5-((7-(4-(3-((4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperazin-1-yl)heptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity:	≥98% (HPLC)

dTAG-7

Catalog #: 6912

Citations (10)

Product Documents

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name:	(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity:	≥98% (HPLC)

TL 13-112

Catalog #: 6745

Citations (2)

Product Documents

Selective ALK Degrader (PROTAC®)

Chemical Name:	N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide
Purity:	≥98% (HPLC)

5-Ph-IAA

Catalog #: 7392

Citations (9)

Product Documents

Selective and potent TAG Degrader for auxin-inducible degron 2 system

Chemical Name:	5-Phenyl-1H-indole-3-acetic acid
Purity:	≥98% (HPLC)

aTAG 2139

Catalog #: 6970

Citations (1)

Product Documents

Degrader of MTH1 fusion proteins for use within the aTAG system

Alternate Names:	CFT 2139
Chemical Name:	6-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
Purity:	≥98% (HPLC)

MZ 1

Catalog #: 6154

Citations (18)

Product Documents

(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4

Chemical Name:	(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)

VHL-SNAP2-5C

Catalog #: 8890

Product Documents

Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins

Chemical Name:	N¹-(4-(((2-Amino-6-chloropyrimidin-4-yl)oxy)methyl)benzyl)-N⁷-((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)heptanediamide
Purity:	≥98% (HPLC)

5-Ph-IAA-AM

Catalog #: 7893

Citations (1)

Product Documents

Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog

Chemical Name:	Acetoxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate
Purity:	≥98% (HPLC)

AT 1

Catalog #: 6356

Citations (3)

Product Documents

(+)-JQ1 based PROTAC® with selectivity for BRD4

Chemical Name:	(2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide
Purity:	≥98% (HPLC)

CRBN PROTAC^® 14a

Catalog #: 7219

Product Documents

Cereblon Degrader (PROTAC®)

Chemical Name:	N¹-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N²⁰-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
Purity:	≥98% (HPLC)

Active Degraders Products

dTAG^V-1

dTAG-13

BromoTag^® AGB1

dTAG^V-1 hydrochloride

aTAG 4531

SNIPER(ER)-87

α-Synuclein Degrader 2b

dBET6

NR 7h

dBET1

ZNL 02-096

MC 1 New

dTAG-47

MS 147

SJFδ

HER2 PROTAC^® CH7C4

dTAG-7

TL 13-112

5-Ph-IAA

aTAG 2139

MZ 1

VHL-SNAP2-5C

5-Ph-IAA-AM

AT 1

CRBN PROTAC^® 14a

CONTACT INFORMATION

保持关注

Active Degraders Products

dTAGV-1

dTAG-13

BromoTag® AGB1

dTAGV-1 hydrochloride

aTAG 4531

SNIPER(ER)-87

α-Synuclein Degrader 2b

dBET6

NR 7h

dBET1

ZNL 02-096

MC 1 New

dTAG-47

MS 147

SJFδ

HER2 PROTAC® CH7C4

dTAG-7

TL 13-112

5-Ph-IAA

aTAG 2139

MZ 1

VHL-SNAP2-5C

5-Ph-IAA-AM

AT 1

CRBN PROTAC® 14a

dTAG^V-1

BromoTag^® AGB1

dTAG^V-1 hydrochloride

HER2 PROTAC^® CH7C4

CRBN PROTAC^® 14a