5-Ph-IAA-AM

Product Description

5-Ph-IAA-AM is a potent and selective "Bump & Hole" TAG Degrader, for use within an auxin-inducible degron (AID2) system; it is an egg-permeant analog of 5-Ph-IAA (Cat. No. 7392). 5-Ph-IAA-AM induces selective degradation of a target protein tagged with a single-point mutant AtTIR1^F79G F-box protein. 5-Ph-IAA-AM induces target protein degradation in C. elegans embryos. No developmental abnormality is observed when the embryos are treated with 50 μM 5-Ph-IAA-AM.

Solubility

Preparing Stock Solutions for 5-Ph-IAA-AM

The following data is based on the product molecular weight 323.35

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.09 mL	15.46 mL	30.93 mL
5 mM	0.62 mL	3.09 mL	6.19 mL
10 mM	0.31 mL	1.55 mL	3.09 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Negishi The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans. Genetics 2022 PMID: 34865044