MS 147
Tocris Bioscience, part of Bio-Techne | Catalog # 8077
PRC1 Degrader (PROTAC®); degrades BMI1 and RING1B
Key Product Details
Description
PRC1 Degrader (PROTAC®); degrades BMI1 and RING1B
Product Description
MS 147 is a polycomb repressive complex 1 (PRC1) Degrader (PROTAC®) (Kd values are 450 nM and 3 μM for VHL and EED, respectively). Comprises an EED binder (EED 226, Cat. No. 7762) joined by a linker to a VHL E3 ligase ligand. MS 147 preferentially degrades BMI1 and RING1B and reduces H2AK119ub in K562 cells. Inhibits proliferation in cancer cell lines that are insensitive to EZH2 knockout or EED/PRC2 Degraders.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Icahn School of Medicine at Mount Sinai.Important Information
This product is sold as an HCl salt. The stoichiometry of the salt and hydration levels vary from batch to batch. It is sold in gross weight and the batch specific Molecular Weight is available on the Certificate of Analysis.Product Specifications
Formula
C54H70N12O6S.xHCl
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
(2S,4R)-1-((S)-2-(7-(5-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)pentanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
InChI Key
WZUKNVLQEQHTMY-RTJWYONCSA-N
SMILES
CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCCNC(CCCCN4CCN(C5=CC=C(C6=CN=C(NCC7=CC=CO7)N8C6=NN=C8)C=C5)CC4)=O)=O)C(C)(C)C)=O)=O)C=C2)SC=N1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 50mg/ml in DMSO |
Calculators
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Park Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy. Adv.Sci. (Weinh.) 2023 PMID: 36737841
Product Specific Notices for MS 147
For research use only
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