EED 226

Name: EED 226
Brand: Tocris Bioscience
SKU: 7762

Tocris Bioscience, part of Bio-Techne | Catalog # 7762

Citations (2)

COA / SDS

Potent and selective EED inhibitor

Key Product Details

Description:	Potent and selective EED inhibitor
Chemical Name:	N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
Purity:	≥98% (HPLC)
Molecular Weight:	369.4

View Full Technical Details for EED 226

Technical Data
Citations

Biological Activity for EED 226

EED 226 is a potent (IC₅₀ = 23.4 nM) and selective EED inhibitor. It inhibits PRC2 activity by binding to the H3K27me3 pocket of EED. The compound shows selectivity for PRC2 complex over protein methyltransferases, kinases, and other protein classes. In vitro, EED 226 regulates histone H3K27 methylation and PRC2 target gene expression. In vivo, it induces tumor regression in a mouse xenograft model. EED 226 is orally bioavailable.

Technical Data for EED 226

M. Wt	369.4
Formula	C₁₇H₁₅N₅O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2083627-02-3
PubChem ID	123132228
InChi Key	DYIRSNMPIZZNBK-UHFFFAOYSA-N
Smiles	O=S(=O)(C1=CC=C(C=C1)C2=CN=C(NCC=3OC=CC3)N4C=NN=C24)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EED 226

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.94	100

Preparing Stock Solutions for EED 226

The following data is based on the product molecular weight 369.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.54 mL	27.07 mL
5 mM	0.54 mL	2.71 mL	5.41 mL
10 mM	0.27 mL	1.35 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for EED 226

References are publications that support the biological activity of the product.

Qi An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nat.Chem.Biol. 2017 PMID: 28135235