dTAGV-1 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 7374
Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use
Key Product Details
Description
Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use
Product Description
dTAGV-1 hydrochloride is a hydrochloride salt of dTAGV-1 (Cat. No. 6914). Suitable for use in vivo. Following ip administration of 10 mg/kg in mice: T½ = 4.43 h; Cmax = 2123 ng mL-1; AUCinf = 18517 hr*ng mL-1 and CL = 9.05 mL min-1 kg-1Negative control dTAGV-1-NEG (Cat. No. 6915) also available.
Important: It is recommended that DMSO stock solutions of this compound are made and used on the same day and are not subjected to freeze/thaw.
Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
1284.01
Formula
C68H90N6O14S.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride
CAS Number
2624313-16-0
InChI Key
WZEDGWVEEAWMSD-LNVAYBNASA-N
SMILES
C[C@H](NC([C@@H]1C[C@@H](O)CN1C([C@@H](NC(CCCCCCNC(COC2=CC=CC=C2[C@H](OC([C@@H]3CCCCN3C([C@@H](CC)C4=CC(OC)=C(OC)C(OC)=C4)=O)=O)CCC5=CC(OC)=C(OC)C=C5)=O)=O)C(C)(C)C)=O)=O)C6=CC=C(C=C6)C7=C(N=CS7)C.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 128.4 | 100 |
Preparing Stock Solutions
for dTAGV-1 hydrochloride
The following data is based on the product molecular weight 1284.01
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.78 mL | 3.89 mL | 7.79 mL |
| 5 mM | 0.16 mL | 0.78 mL | 1.56 mL |
| 10 mM | 0.08 mL | 0.39 mL | 0.78 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.16 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Abuhashem Generation of knock-in degron tags for endogenous proteins in mice using the dTAG system. STAR Protoc. 2022 PMID: 36097386
- Nabet Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat.Commun. 2020 PMID: 32948771
Product Specific Notices for dTAGV-1 hydrochloride
For research use only
Loading...
Loading...
Loading...