VHL-SNAP2-5C

Tocris Bioscience, part of Bio-Techne | Catalog # 8890

Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins
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Key Product Details

Description

Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins

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Product Description

VHL-SNAP2-5C is a Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins (Dmax = 80% at 1 μM). VHL-SNAP2-5C recruits VHL E3 ligase to induce the degradation of SNAP-fusion proteins.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

SNAP-tag is a trademark of New England BioLabs, Inc.

Product Specifications

Molecular Weight

833.45

Formula

C42H53ClN8O6S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N1-(4-(((2-Amino-6-chloropyrimidin-4-yl)oxy)methyl)benzyl)-N7-((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)heptanediamide

InChI Key

RZNBOJVEQRLLQS-WWGNEEHCSA-N

SMILES

CC1=C(SC=N1)C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCC(NCC4=CC=C(COC5=NC(N)=NC(Cl)=C5)C=C4)=O)=O)C(C)(C)C)=O)=O)C)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 83.34 100

Preparing Stock Solutions for VHL-SNAP2-5C

The following data is based on the product molecular weight 833.45

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.20 mL 6.00 mL 12.00 mL
5 mM 0.24 mL 1.20 mL 2.40 mL
10 mM 0.12 mL 0.60 mL 1.20 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VHL-SNAP2-5C

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VHL-SNAP2-5C

For research use only

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