16 results for "STING/TMEM173 Small Molecules and Peptides" in Products
STING/TMEM173: Small Molecules and Peptides
[[URL:https://www.novusbio.com/common-name/sting-tmem173]][[Caption:STING]] (stimulator of interferon genes) is encoded by the TMEM173 gene and is an adaptor molecule involved in the activation of [[URL:https://www.novusbio.com/research-areas/immunology/innate-immunity]][[C… immune responses]] to [[URL:https://www.novusbio.com/research-areas/immunology/toll-receptors-tlr]]…]] (pathogen-associated molecular patterns) and ...
Pan-polymorph STING agonist
| Chemical Name: | 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide |
| Purity: | ≥98% (HPLC) |
Negative control for STING Degrader SP23 (Cat. No. 8053)
| Chemical Name: | (2E)-N1-[6-[[2,3-Dihydro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide |
| Purity: | ≥98% (HPLC) |
Selective STING Degrader (PROTAC®)
| Chemical Name: | (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide |
| Purity: | ≥98% (HPLC) |
Endogenous high affinity STING agonist
| Chemical Name: | 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt |
| Purity: | ≥98% (HPLC) |
Non-nucleotide STING agonist; orally bioavailable
| Chemical Name: | 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid |
| Purity: | ≥98% (HPLC) |
mSTING agonist; induces antitumor immunological responses
| Chemical Name: | 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid |
| Purity: | ≥98% (HPLC) |
STING agonist
| Chemical Name: | [P(R)]-5'-O-[(R)-Hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine cyclic nucleotide disodium |
| Purity: | ≥95% (HPLC) |
STING antagonist
| Chemical Name: | N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea |
| Purity: | ≥98% (HPLC) |
Endogenous STING and DDX41 agonist; activates STING-dependent signaling
| Chemical Name: | 3',5'-Cyclic diguanylic acid sodium salt |
| Purity: | ≥98% (HPLC) |
mSTING antagonist
| Purity: | ≥97% (HPLC) |
Murine-selective STING agonist
| Chemical Name: | 9-Oxo-10(9H)-acridineacetic acid |
| Purity: | ≥98% (HPLC) |
STING agonist, molecular glue that causes oligomerization of STING
| Chemical Name: | 4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid |
| Purity: | ≥98% (HPLC) |
Induces expression of STING and STING-related genes; antiviral
| Chemical Name: | 3',2'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt |
| Purity: | ≥98% (HPLC) |
Inhibitor of STING-TRIM29 interaction; increases cellular STING levels
| Chemical Name: | 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide |
| Purity: | ≥98% (HPLC) |
Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)
| Alternate Names: | RU320521 |
| Chemical Name: | 3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-1(3H)-isobenzofuranone |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of cyclic GMP-AMP synthase (cGAS)
| Chemical Name: | Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate |
| Purity: | ≥98% (HPLC) |
