16 results for "STING/TMEM173 Small Molecules and Peptides" in Products
STING/TMEM173: Small Molecules and Peptides
STING (stimulator of interferon genes) is encoded by the TMEM173 gene and is an adaptor molecule involved in the activation of innate immune responses to PAMPS (pathogen-associated molecular patterns) and DAMPS (damage-associated molecular patterns). STING specifically recognizes cytosolic DNA products derived from pathogens (e.g., cytomegalovirus, vaccinia virus, Listeria monocytogenes or dead cells (1, 2). In the STING pathway, dsDNA derived from pathogens or damaged cells serves as a ...
Pan-polymorph STING agonist
| Chemical Name: | 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide |
| Purity: | ≥98% (HPLC) |
Negative control for STING Degrader SP23 (Cat. No. 8053)
| Chemical Name: | (2E)-N1-[6-[[2,3-Dihydro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide |
| Purity: | ≥98% (HPLC) |
Selective STING Degrader (PROTAC®)
| Chemical Name: | (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide |
| Purity: | ≥98% (HPLC) |
Non-nucleotide STING agonist; orally bioavailable
| Chemical Name: | 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid |
| Purity: | ≥98% (HPLC) |
mSTING agonist; induces antitumor immunological responses
| Chemical Name: | 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid |
| Purity: | ≥98% (HPLC) |
STING antagonist
| Chemical Name: | N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea |
| Purity: | ≥98% (HPLC) |
Endogenous high affinity STING agonist
| Chemical Name: | 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt |
| Purity: | ≥98% (HPLC) |
STING agonist, molecular glue that causes oligomerization of STING
| Chemical Name: | 4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid |
| Purity: | ≥98% (HPLC) |
Inhibitor of STING-TRIM29 interaction; increases cellular STING levels
| Chemical Name: | 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide |
| Purity: | ≥98% (HPLC) |
Induces expression of STING and STING-related genes; antiviral
| Chemical Name: | 3',2'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt |
| Purity: | ≥98% (HPLC) |
STING agonist
| Chemical Name: | [P(R)]-5'-O-[(R)-Hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine cyclic nucleotide disodium |
| Purity: | ≥95% (HPLC) |
mSTING antagonist
| Purity: | ≥97% (HPLC) |
Endogenous STING and DDX41 agonist; activates STING-dependent signaling
| Chemical Name: | 3',5'-Cyclic diguanylic acid sodium salt |
| Purity: | ≥98% (HPLC) |
Murine-selective STING agonist
| Chemical Name: | 9-Oxo-10(9H)-acridineacetic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)
| Alternate Names: | RU320521 |
| Chemical Name: | 3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-1(3H)-isobenzofuranone |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of cyclic GMP-AMP synthase (cGAS)
| Chemical Name: | Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate |
| Purity: | ≥98% (HPLC) |
