STING Degrader SP23
Tocris Bioscience, part of Bio-Techne | Catalog # 8053
Selective STING Degrader (PROTAC®)
Product Description
STING Degrader SP23 is a selective stimulator of interferon gene (STING) Degrader (PROTAC®; DC50 = 3.2 μM). Comprises the STING inhibitor (C-170), joined by a linker to a CRBN ligand Pomalidomide (Cat. No. 6302). It does not degrade JAK2, STAT3, PI 3-K, AKT and TLR4 in THP-1 cells. STING Degrader SP23 dose dependently reduces the levels of IFN-β, IL-6, and CXCL10 triggered by cGAMP in THP-1 cells; it also modulates the downstream signals of the STING signaling pathway in vivo. STING Degrader SP23 has high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model.Negative control STING Degrader N-Me-SP23 (Cat. No. 8054) and STING/TMEM173 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF6516 and NBP3-18816.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
699.68
Formula
C34H33N7O10
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
CAS Number
2762552-74-7
PubChem ID
164886634
InChI Key
TXNQXRGOKABDOB-FOCLMDBBSA-N
SMILES
O=C1C2=C(NCCCCCCNC(/C=C/C(NC3=CC=C(C=C3)NC(C4=CC=C(N(=O)=O)O4)=O)=O)=O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 69.97 | 100 |
Preparing Stock Solutions
for STING Degrader SP23
The following data is based on the product molecular weight 699.68
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.43 mL | 7.15 mL | 14.29 mL |
| 5 mM | 0.29 mL | 1.43 mL | 2.86 mL |
| 10 mM | 0.14 mL | 0.71 mL | 1.43 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu Novel CRBN-recruiting proteolysis-targeting chimeras as degraders of stimulator of interferon genes with in vivo anti- inflammatory efficacy. J.Med.Chem. 2022 PMID: 35452223
Product Specific Notices for STING Degrader SP23
For research use only
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