STING Degrader SP23

Name: STING Degrader SP23
Brand: Tocris Bioscience
SKU: 8053

Tocris Bioscience, part of Bio-Techne | Catalog # 8053

COA / SDS

Selective STING Degrader (PROTAC®)

Key Product Details

Description:	Selective STING Degrader (PROTAC^®)
Chemical Name:	(2E)-N¹-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N⁴-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
Purity:	≥98% (HPLC)
Molecular Weight:	699.68

View Full Technical Details for STING Degrader SP23

Technical Data
Citations

Biological Activity for STING Degrader SP23

STING Degrader SP23 is a selective stimulator of interferon gene (STING) Degrader (PROTAC^®; DC₅₀ = 3.2 μM). Comprises the STING inhibitor (C-170), joined by a linker to a CRBN ligand Pomalidomide (Cat. No. 6302). It does not degrade JAK2, STAT3, PI 3-K, AKT and TLR4 in THP-1 cells. STING Degrader SP23 dose dependently reduces the levels of IFN-β, IL-6, and CXCL10 triggered by cGAMP in THP-1 cells; it also modulates the downstream signals of the STING signaling pathway in vivo. STING Degrader SP23 has high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model.

Negative control STING Degrader N-Me-SP23 (Cat. No. 8054) and STING/TMEM173 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF6516 and NBP3-18816.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for STING Degrader SP23

M. Wt	699.68
Formula	C₃₄H₃₃N₇O₁₀
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2762552-74-7
PubChem ID	164886634
InChi Key	TXNQXRGOKABDOB-FOCLMDBBSA-N
Smiles	O=C1C2=C(NCCCCCCNC(/C=C/C(NC3=CC=C(C=C3)NC(C4=CC=C(N(=O)=O)O4)=O)=O)=O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for STING Degrader SP23

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	69.97	100

Preparing Stock Solutions for STING Degrader SP23

The following data is based on the product molecular weight 699.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.43 mL	7.15 mL	14.29 mL
5 mM	0.29 mL	1.43 mL	2.86 mL
10 mM	0.14 mL	0.71 mL	1.43 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

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References for STING Degrader SP23

References are publications that support the biological activity of the product.

Liu Novel CRBN-recruiting proteolysis-targeting chimeras as degraders of stimulator of interferon genes with in vivo anti- inflammatory efficacy. J.Med.Chem. 2022 PMID: 35452223