C 176

Name: C 176
Brand: Tocris Bioscience
SKU: 7040

Tocris Bioscience, part of Bio-Techne | Catalog # 7040

Citations (9)

COA / SDS

mSTING antagonist

Key Product Details

Description:	mSTING antagonist
Purity:	≥97% (HPLC)
Molecular Weight:	358.09

View Full Technical Details for C 176

Technical Data
Citations

Biological Activity for C 176

C 176 is a mSTING antagonist. Covalently binds Cys91 of mouse but not human STING. Blocks activation-induced palmitoylation of STING and formation of STING clusters. Reduces CMA (Cat. No. 6677) -induced increase in serum IFNs in vivo and suppresses systemic inflammation in a mouse inflammatory disease model.

Technical Data for C 176

M. Wt	358.09
Formula	C₁₁H₇IN₂O₄
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	314054-00-7
PubChem ID	1103958
InChi Key	JBIKQXOZLBLMKI-UHFFFAOYSA-N
Smiles	IC1=CC=C(C=C1)NC(C2=CC=C([N+]([O-])=O)O2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C 176

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.81	100

Preparing Stock Solutions for C 176

The following data is based on the product molecular weight 358.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.96 mL	27.93 mL
5 mM	0.56 mL	2.79 mL	5.59 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for C 176

References are publications that support the biological activity of the product.

Haag Targeting STING with covalent small-molecule inhibitors. Nature 2018 PMID: 29973723