NVS-STG2

Name: NVS-STG2
Brand: Tocris Bioscience
SKU: 8120

Tocris Bioscience, part of Bio-Techne | Catalog # 8120

COA / SDS

STING agonist, molecular glue that causes oligomerization of STING

Key Product Details

Description:	STING agonist, molecular glue that causes oligomerization of STING
Chemical Name:	4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	427.54

View Full Technical Details for NVS-STG2

Technical Data
Citations

Biological Activity for NVS-STG2

NVS-STG2 is a STING agonist. It induces oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, acting as a molecular glue. NVS-STG2 elicits potent STING-mediated immune responses in cells and produces antitumor activities in hSTING knock-in mice.

Technical Data for NVS-STG2

M. Wt	427.54
Formula	C₂₅H₃₃NO₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3030588-01-0
PubChem ID	168719774
InChi Key	CZSPKEVHLRWAFC-UHFFFAOYSA-N
Smiles	OC(C1=CC=C(C(OC)=C1)NCC2=CC=C(C=C2)C3(OCC(C)(CO3)C)C(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NVS-STG2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.75	100

Preparing Stock Solutions for NVS-STG2

The following data is based on the product molecular weight 427.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.69 mL	23.39 mL
5 mM	0.47 mL	2.34 mL	4.68 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for NVS-STG2

References are publications that support the biological activity of the product.

Li Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol. 2024 PMID: 37828400