MSA 2

Name: MSA 2
Brand: Tocris Bioscience
SKU: 7353

Tocris Bioscience, part of Bio-Techne | Catalog # 7353

Citations (2)

COA / SDS

Non-nucleotide STING agonist; orally bioavailable

Key Product Details

Description:	Non-nucleotide STING agonist; orally bioavailable
Chemical Name:	4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	294.32

View Full Technical Details for MSA 2

Technical Data
Citations

Biological Activity for MSA 2

MSA 2 is a non-nucleotide STING agonist (EC₅₀ values are 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon-β secretion in tumors. Induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models. Orally bioavailable.

Compound Libraries for MSA 2

MSA 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MSA 2

M. Wt	294.32
Formula	C₁₄H₁₄O₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	129425-81-6
PubChem ID	23035251
InChi Key	APCLRHPWFCQIMG-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C=C1OC)C=C(C(CCC(O)=O)=O)S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MSA 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.43	100

Preparing Stock Solutions for MSA 2

The following data is based on the product molecular weight 294.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	16.99 mL	33.98 mL
5 mM	0.68 mL	3.40 mL	6.80 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Reconstitution Calculator

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References for MSA 2

References are publications that support the biological activity of the product.

Pan An orally available non-nucleotide STING agonist with antitumor activity. Science 2020 PMID: 32820094