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P2X Receptor Antagonists: Small Molecules and Peptides

ATP-gated ion channels, P2X purinergic receptors are composed of three subunits. They confer specific receptor subtype pharmacology and are permeable to cations.

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22 results for "P2X Receptor Antagonists Small Molecules and Peptides" in Products

22 results for "P2X Receptor Antagonists Small Molecules and Peptides" in Products

P2X Receptor Antagonists: Small Molecules and Peptides

ATP-gated ion channels, P2X purinergic receptors are composed of three subunits. They confer specific receptor subtype pharmacology and are permeable to cations.

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Competitive P2X7 antagonist

Chemical Name: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride
Purity: ≥98% (HPLC)
Competitive P2X7 antagonist

Highly selective P2X1 antagonist

Chemical Name: 4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid, octasodium salt
Purity: ≥90% (HPLC)
Highly selective P2X1 antagonist

Potent and selective P2X7 antagonist

Chemical Name: N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
Purity: ≥97% (HPLC)
Potent and selective P2X7 antagonist

Potent and selective P2X antagonist

Chemical Name: 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt
Purity: ≥95% (HPLC)
Potent and selective P2X antagonist

Non-selective P2 antagonist

Chemical Name: Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt
Non-selective P2 antagonist

Non-competitive P2X7 antagonist

Chemical Name: 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester
Purity: ≥98% (HPLC)
Non-competitive P2X7 antagonist

Non-selective P2X antagonist

Chemical Name: Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Non-selective P2X antagonist

Potent and selective P2X4 antagonist

Chemical Name: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
Purity: ≥98% (HPLC)
Potent and selective P2X4 antagonist

Non-selective P2 antagonist

Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Purity: ≥98% (HPLC)
Non-selective P2 antagonist

Selective P2Y11 and P2X1 antagonist

Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Purity: ≥90% (HPLC)
Selective P2Y11 and P2X1 antagonist

Selective and competitive P2X1 antagonist

Chemical Name: 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt
Selective and competitive P2X1 antagonist

Potent and selective P2X7 antagonist

Chemical Name: N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine
Purity: ≥98% (HPLC)
Potent and selective P2X7 antagonist

Selective P2X3 and P2X2/3 antagonist

Chemical Name: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Selective P2X3 and P2X2/3 antagonist

Potent P2X7 antagonist

Chemical Name: N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride
Purity: ≥98% (HPLC)
Potent P2X7 antagonist

Potent and selective human P2X7 antagonist

Chemical Name: 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Potent and selective human P2X7 antagonist

Selective P2X4 allosteric antagonist

Chemical Name: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea
Purity: ≥98% (HPLC)
Selective P2X4 allosteric antagonist

Potent and selective P2X7 antagonist; brain penetrant

Chemical Name: 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide
Purity: ≥98% (HPLC)
Potent and selective P2X7 antagonist; brain penetrant

Potent and selective P2X1 antagonist

Chemical Name: 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Purity: ≥95% (HPLC)
Potent and selective P2X1 antagonist

Dye for assessing cell viability and blood brain barrier permeability; also EAAT inhibitor and iGluR antagonist

Chemical Name: 6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)bis[4-amino- 5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt
Purity: ≥90% (HPLC)
Dye for assessing cell viability and blood brain barrier permeability; also EAAT inhibitor and iGluR antagonist

Potent P2X3 antagonist

Chemical Name: 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt
Purity: ≥90% (HPLC)
Potent P2X3 antagonist

Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive

Chemical Name: 5-[[[(3-Phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt
Purity: ≥98% (HPLC)
Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive

Selective P2X4 antagonist

Chemical Name: N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide
Purity: ≥98% (HPLC)
Selective P2X4 antagonist
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