NF 157
Tocris Bioscience, part of Bio-Techne | Catalog # 2450
Selective P2Y11 and P2X1 antagonist
Key Product Details
Description
Selective P2Y11 and P2X1 antagonist
Product Description
NF 157 is a purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2 , P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.
Product Specifications
Molecular Weight
1437.08
Formula
C49H28F2N6Na6O23S6
Storage
Desiccate at RT
Purity
≥90% (HPLC)
Chemical Name
8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
CAS Number
104869-26-3
PubChem ID
71433548
InChI Key
QJFCMJZVZFAWGF-UHFFFAOYSA-H
SMILES
[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]OOSC1=C2C(NC(=O)C3=CC(NC(=O)C4=CC(NC(=O)NC5=CC(=CC=C5)C(=O)NC5=CC(=CC=C5F)C(=O)NC5=CC=C(C6=CC(=CC(=C56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C4)=C(F)C=C3)=CC=C(C2=CC(=C1)S([O-])(=O)=O)S([O-])(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5 | ||
| DMSO | 10 |
Preparing Stock Solutions
for NF 157
The following data is based on the product molecular weight 1437.08
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.07 mM | 9.94 mL | 49.70 mL | 99.41 mL |
| 0.35 mM | 1.99 mL | 9.94 mL | 19.88 mL |
| 0.7 mM | 0.99 mL | 4.97 mL | 9.94 mL |
| 3.5 mM | 0.20 mL | 0.99 mL | 1.99 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Moreschi Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes. J.Biol.Chem. 2006 PMID: 16926152
- Ullmann Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J.Med.Chem. 2005 PMID: 16250663
Product Specific Notices for NF 157
For research use only
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