TNP-ATP triethylammonium salt

Name: TNP-ATP triethylammonium salt
Brand: Tocris Bioscience
SKU: 2464

Tocris Bioscience, part of Bio-Techne | Catalog # 2464

Citations (17)

COA / SDS

Potent and selective P2X antagonist

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Technical Data
Citations & Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective P2X antagonist

View all P2X Receptor Antagonists »

Product Description

TNP-ATP triethylammonium salt is a high affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X₁, P2X₃ and heteromeric P2X_2/3 receptors with IC₅₀ values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X₂, P2X₄ and P2X₇.

Product Specifications

Molecular Weight

1123.04

Formula

C₁₆H₁₃N₈O₁₉P₃.4C₆H₁₆N

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt

PubChem ID

75358143

InChI Key

XTSNRUFLZVGKOU-NRBYJGOSSA-O

SMILES

NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])(O)=O)([O-])=O)([O-])=O)[C@]4([H])[C@]([H])3OC(C([N+]([O-])=O)=C/C(C=C5[N+]([O-])=O)=[N+]([O-])/[O-])5O4)C=N2)=NC=N1.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Spelta Kinetics of antagonist actions at rat P2X_2/3 heteromeric receptors. Br.J.Pharmacol. 2002 PMID: 11906966
Burgard Competitive antagonism of recombinant P2X_(2/3)receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP). Mol.Pharmacol. 2000 PMID: 11093790
Lewis 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 1998 PMID: 9723959
Thomas The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 1998 PMID: 9575290
Virginio Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X₁, P2X₃ and heteromeric P2X_2/3 receptors. Mol.Pharmacol. 1998 PMID: 9614197