JNJ 47965567

Tocris Bioscience, part of Bio-Techne | Catalog # 5299

Potent and selective P2X7 antagonist; brain penetrant
Catalog #
Availability
Size / Price
Qty
5299/10
5299/50
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

Potent and selective P2X7 antagonist; brain penetrant

View all P2X Receptor Antagonists »

Product Description

JNJ 47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP-induced IL-1β release from monocytes in vitro and from rat brain in vivo. Attenuates amphetamine-induced hyperactivity in rats. Brain penetrant.

Product Specifications

Molecular Weight

488.64

Formula

C28H32N4O2S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide

CAS Number

1428327-31-4

PubChem ID

66553218

InChI Key

XREFXUCWSYMIOG-UHFFFAOYSA-N

SMILES

O=C(NCC4(CCOCC4)N3CCN(C5=CC=CC=C5)CC3)C1=CC=CN=C1SC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 24.43 50
DMSO 48.86 100

Preparing Stock Solutions for JNJ 47965567

The following data is based on the product molecular weight 488.64

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.23 mL 20.46 mL
5 mM 0.41 mL 2.05 mL 4.09 mL
10 mM 0.20 mL 1.02 mL 2.05 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for JNJ 47965567

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JNJ 47965567

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.