NF 023
Tocris Bioscience, part of Bio-Techne | Catalog # 1240
Selective and competitive P2X1 antagonist
Key Product Details
Description
Selective and competitive P2X1 antagonist
Product Description
NF 023 is an a subtype-selective, competitive and reversible P2X1 receptor antagonist. Displays IC50 values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α-subunit of Go/i (EC50 ~300 nM). Also inhibits DNA-binding activity of HMGA2 (IC50 = 10.63 μM).Product Specifications
Molecular Weight
1162.86
Formula
C35H20N4Na6O21S6
Storage
Desiccate at RT
Chemical Name
8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt
CAS Number
104869-31-0
PubChem ID
4465
InChI Key
FMQURVHYTBGYSQ-UHFFFAOYSA-H
SMILES
[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC2=C(C=CC(NC(=O)C3=CC=CC(NC(=O)NC4=CC(=CC=C4)C(=O)NC4=C5C(C=C(C=C5S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C4)S([O-])(=O)=O)=C3)=C2C(=C1)S([O-])(=O)=O)S([O-])(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
for NF 023
The following data is based on the product molecular weight 1162.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.86 mL | 4.30 mL | 8.60 mL |
| 5 mM | 0.17 mL | 0.86 mL | 1.72 mL |
| 10 mM | 0.09 mL | 0.43 mL | 0.86 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Su Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci.Rep. 2020 PMID: 33139812
- Van Rhee Novel competitive antagonists for P2 purinoceptors. Eur.J.Pharmacol. 1994 PMID: 7925607
- Sneddon The effect of P2 receptor antagonists and ATPase inhibition on sympathetic purinergic neurotransmission in the guinea-pig isolated vas deferens. Br.J.Pharmacol. 2000 PMID: 10725256
- Soto Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology 1999 PMID: 10193905
- Freissmuth Suramin analogues as subtype-selective G protein inhibitors. Mol.Pharmacol. 1996 PMID: 8609887
Product Specific Notices for NF 023
For research use only
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