NF 279
Tocris Bioscience, part of Bio-Techne | Catalog # 1199
Potent and selective P2X1 antagonist
Key Product Details
Description
Potent and selective P2X1 antagonist
Product Description
NF 279 is a a potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
Product Specifications
Molecular Weight
1401.10
Formula
C49H30N6Na6O23S6
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
CAS Number
202983-32-2
PubChem ID
4467
InChI Key
RJMCMLNRWDKUDB-UHFFFAOYSA-H
SMILES
[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC2=C(C(NC(=O)C3=CC=C(NC(=O)C4=CC=C(NC(=O)NC5=CC=C(C=C5)C(=O)NC5=CC=C(C=C5)C(=O)NC5=C6C(C=C(C=C6S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C5)S([O-])(=O)=O)C=C4)C=C3)=CC=C2S([O-])(=O)=O)C(=C1)S([O-])(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25 |
Preparing Stock Solutions
for NF 279
The following data is based on the product molecular weight 1401.10
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.18 mM | 3.97 mL | 19.83 mL | 39.65 mL |
| 0.9 mM | 0.79 mL | 3.97 mL | 7.93 mL |
| 1.8 mM | 0.40 mL | 1.98 mL | 3.97 mL |
| 9 mM | 0.08 mL | 0.40 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Klapperstuck Antagonism by the suramin analogue NF 279 on human P2X1 and P2X7 receptors. Eur.J.Pharmacol. 2000 PMID: 10650169
- Rettinger The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor. Neuropharmacology 2000 PMID: 10963748
- Damer NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. Eur.J.Pharmacol. 1998 PMID: 9683026
Product Specific Notices for NF 279
For research use only
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