PPADS tetrasodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 0625
Non-selective P2 antagonist
Product Description
PPADS tetrasodium salt is a non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. PPADS tetrasodium salt delays onset of calcium responses to mild hypoosmotic stress in cortical slices. PPADS tetrasodium salt blocks P2X7 and reduces clinical and histological graft-versus-host disease development in a humanised mouse model.2'5'-isomer also available.
Product Specifications
Molecular Weight
599.30
Formula
C14H10N3Na4O12PS2
Storage
Desiccate at -20°C
Chemical Name
Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt
CAS Number
192575-19-2
PubChem ID
101086948
InChI Key
KURWUCJJNVPCHT-UHFFFAOYSA-J
SMILES
[Na+].[Na+].[Na+].[Na+].CC1=C(O)C(C=O)=C(COP([O-])([O-])=O)C(\N=N\C2=C(C=C(C=C2)S([O-])(=O)=O)S([O-])(=O)=O)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
for PPADS tetrasodium salt
The following data is based on the product molecular weight 599.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.67 mL | 8.34 mL | 16.69 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.67 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cuthbertson P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model. Clin.Sci. 2021 PMID: 33463682
- Thrane Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc.Natl.Acad.Sci.U S A 2011 PMID: 21187412
- Ralevic and Burnstock Receptors for purines and pyrimidines. Pharmacol.Rev. 1998 PMID: 9755289
- McLaren Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens. Br.J.Pharmacol. 1994 PMID: 8019769
- Lambrecht PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur.J.Pharmacol. 1992 PMID: 1330591
- Ziganshin Selective antagonism by PPADS at P2x-purinoceptors in rabbit isolated blood vessels. Br.J.Pharmacol. 1994 PMID: 8019770
Product Specific Notices for PPADS tetrasodium salt
For research use only
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