A 438079 hydrochloride

Name: A 438079 hydrochloride
Brand: Tocris Bioscience
SKU: 2972

Tocris Bioscience, part of Bio-Techne | Catalog # 2972

Citations (63)

COA / SDS

Competitive P2X7 antagonist

Key Product Details

Description:	Competitive P2X₇ antagonist
Chemical Name:	3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	342.61

View Full Technical Details for A 438079 hydrochloride

Technical Data
Citations

Biological Activity for A 438079 hydrochloride

A 438079 hydrochloride is a competitive P2X₇ receptor antagonist (pIC₅₀ = 6.9 for the inhibition of Ca²⁺ influx in the human recombinant P2X₇ cell line). Devoid of activity at other P2 receptors (IC₅₀ > 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo. Inhibits methamphetamine-induced microglial migration and phagocytosis in vitro.

Compound Libraries for A 438079 hydrochloride

A 438079 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 438079 hydrochloride

M. Wt	342.61
Formula	C₁₃H₉Cl₂N₅.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	899431-18-6
PubChem ID	11688742
InChi Key	MBTJFFMIPPMRGR-UHFFFAOYSA-N
Smiles	ClC1=C(C2=NN=NN2CC3=CN=CC=C3)C=CC=C1Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 438079 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.26	100

Preparing Stock Solutions for A 438079 hydrochloride

The following data is based on the product molecular weight 342.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.59 mL	29.19 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for A 438079 hydrochloride

References are publications that support the biological activity of the product.

Fernandes Methamphetamine alters microglial immune function through P2X₇R signaling. J.Neuroinflammation. 2016 PMID: 27117066
Donnelly-Roberts and Jarvis Discovery of P2X₇ receptor-selective antagonists offers new insights into P2X₇ receptor function and indicates a role in chronic pain states. Br.J.Pharmacol. 2007 PMID: 17471177
McGaraughty P2X₇-related modulation of pathological nociception in rats. Neuroscience 2007 PMID: 17478048
Nelson Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X₇ antagonists. J.Med.Chem. 2006 PMID: 16759108