A 438079 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2972

Competitive P2X7 antagonist
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Key Product Details

Description

Competitive P2X7 antagonist

View all P2X Receptor Antagonists »

Product Description

A 438079 hydrochloride is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 > 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo. Inhibits methamphetamine-induced microglial migration and phagocytosis in vitro.

Product Specifications

Molecular Weight

342.61

Formula

C13H9Cl2N5.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride

CAS Number

899431-18-6

PubChem ID

11688742

InChI Key

MBTJFFMIPPMRGR-UHFFFAOYSA-N

SMILES

ClC1=C(C2=NN=NN2CC3=CN=CC=C3)C=CC=C1Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.26 100

Preparing Stock Solutions for A 438079 hydrochloride

The following data is based on the product molecular weight 342.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.59 mL 29.19 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for A 438079 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 438079 hydrochloride

For research use only

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