mGluR5: Small Molecules and Peptides
Human metabotropic glutamate receptor 5 (mGluR5; also mGluR5b) is a 150 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. mGluR5 is constitutively expressed and regulates neuronal ion channel activity. Human mGluR5 is 1212 amino acids (aa) in length and contains an extracellular domain (ECD) of 558 amino acids. Through its ECD, mGluR5 either homodimerizes or heterodimerizes with the Ca2+-sensor receptor. There is one alternate splice form (mGluR5a) that shows a 32 aa deletion between aa 877 - 908 in the cytoplasmic tail. Over aa 19 - 509, human mGluR5 is 98% aa identical to mouse, rat, and canine mGluR5.
18 results for "mGluR5 Small Molecules and Peptides" in Products
18 results for "mGluR5 Small Molecules and Peptides" in Products
mGluR5: Small Molecules and Peptides
Human metabotropic glutamate receptor 5 (mGluR5; also mGluR5b) is a 150 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. mGluR5 is constitutively expressed and regulates neuronal ion channel activity. Human mGluR5 is 1212 amino acids (aa) in length and contains an extracellular domain (ECD) of 558 amino acids. Through its ECD, mGluR5 either homodimerizes or heterodimerizes with the Ca2+-sensor receptor. There is one alternate splice form (mGluR5a) that shows a 32 aa deletion between aa 877 - 908 in the cytoplasmic tail. Over aa 19 - 509, human mGluR5 is 98% aa identical to mouse, rat, and canine mGluR5.
Active metabolite of oxcarbazepine (Cat. No. 3864)
| Alternate Names: | GP 47779 |
| Chemical Name: | 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide |
| Purity: | ≥98% (HPLC) |
Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
| Chemical Name: | 2-Methyl-6-(phenylethynyl)pyridine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective mGlu5 agonist; sodium salt of CHPG (Cat. No. 1049)
| Chemical Name: | (RS)-2-Chloro-5-hydroxyphenylglycine sodium salt |
| Purity: | ≥99% (HPLC) |
mGlu5 selective agonist
| Chemical Name: | (RS)-2-Chloro-5-hydroxyphenylglycine |
| Purity: | ≥99% (HPLC) |
Potent and selective mGlu5 antagonist
| Chemical Name: | 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective mGlu5 antagonist; brain penetrant
| Chemical Name: | 3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile |
| Purity: | ≥98% (HPLC) |
Potent and selective mGlu5 negative allosteric modulator (NAM)
| Chemical Name: | N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea |
| Purity: | ≥98% (HPLC) |
Group I mGlu antagonist
| Chemical Name: | N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide |
| Purity: | ≥98% (HPLC) |
AMPA agonist; also group I mGlu agonist
| Chemical Name: | (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid |
| Purity: | ≥99% (HPLC) |
Positive allosteric modulator of group I mGlu receptors
| Chemical Name: | (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester |
| Purity: | ≥98% (HPLC) |
Potent group I mGlu antagonist
| Chemical Name: | N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of mGlu5 receptors
| Chemical Name: | 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of mGlu5 receptors
| Chemical Name: | N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Negative allosteric modulator of mGlu5 receptors
| Alternate Names: | Raseglurant |
| Chemical Name: | 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride |
| Purity: | ≥98% (HPLC) |
GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors
| Alternate Names: | Topamax |
| Chemical Name: | 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate |
| Purity: | ≥98% (HPLC) |
Selective positive allosteric modulator of mGlu5 receptors; brain penetrant and orally bioavailable
| Alternate Names: | JNJ 46778212 |
| Chemical Name: | [6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone |
| Purity: | ≥98% (HPLC) |
mGlu5 antagonist; orally bioavailable and brain penetrant
| Chemical Name: | 4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine |
| Purity: | ≥98% (HPLC) |
Potent and selective positive allosteric modulator of mGlu5 receptors
| Chemical Name: | N-(1-Methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
