MTEP hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2921
Potent and selective mGlu5 antagonist
Key Product Details
Description
Potent and selective mGlu5 antagonist
Product Description
MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki= 16 nM). Displays anxiolytic activity in vivo and is orally active.Licensing Information
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)Product Specifications
Molecular Weight
236.72
Formula
C11H8N2S.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
CAS Number
1186195-60-7
PubChem ID
45073467
InChI Key
YCIOJDKGCWAHLR-UHFFFAOYSA-N
SMILES
CC1=NC(C#CC2=CN=CC=C2)=CS1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.67 | 100 | |
| DMSO | 23.67 | 100 |
Preparing Stock Solutions
for MTEP hydrochloride
The following data is based on the product molecular weight 236.72
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.22 mL | 21.12 mL | 42.24 mL |
| 5 mM | 0.84 mL | 4.22 mL | 8.45 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brodkin Reduced stress-induced hyperthermia in mGluR5 knockout mice. Eur.J.Neurosci. 2002 PMID: 12473093
- Cosford 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J.Med.Chem. 2003 PMID: 12519057
- Roppe 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity. Bioorg.Med.Chem.Lett. 2004 PMID: 15225713
- Klodzinska Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABAA signaling. Neuropharmacology 2004 PMID: 15275823
- Bradbury Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. J.Pharmacol.Exp.Ther. 2005 PMID: 15590770
Product Specific Notices for MTEP hydrochloride
For research use only
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