CDPPB
Tocris Bioscience, part of Bio-Techne | Catalog # 3235
Positive allosteric modulator of mGlu5 receptors
Key Product Details
Description
Positive allosteric modulator of mGlu5 receptors
Product Description
CDPPB is a brain penetrant, selective positive allosteric modulator at the mGlu5 receptor (EC50 values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.Licensing Information
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)Product Specifications
Molecular Weight
364.40
Formula
C23H16N4O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
CAS Number
781652-57-1
PubChem ID
11245456
InChI Key
BKUIZWILNWHFHD-UHFFFAOYSA-N
SMILES
O=C(C4=CC(C#N)=CC=C4)NC1=CC(C3=CC=CC=C3)=NN1C2=CC=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.33 | 75 |
Preparing Stock Solutions
for CDPPB
The following data is based on the product molecular weight 364.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 3.66 mL | 18.29 mL | 36.59 mL |
| 3.75 mM | 0.73 mL | 3.66 mL | 7.32 mL |
| 7.5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 37.5 mM | 0.07 mL | 0.37 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kinney A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rats behavioral models. J.Pharmacol.Exp.Ther. 2005 PMID: 15608073
- Chen Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol.Pharmacol. 2007 PMID: 17303702
- Lindsley Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J.Med.Chem. 2004 PMID: 15537338
Product Specific Notices for CDPPB
For research use only
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