PHCCC
Tocris Bioscience, part of Bio-Techne | Catalog # 1027
Potent group I mGlu antagonist
Product Description
PHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM); 67 times more potent than (S)-4-carboxyphenylglycine (Cat. No. 0323). Also a positive allosteric modulator for mGlu4a; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. Displays antiParkinsonian effects in rats in vivo.Licensing Information
Sold for research purposes under license from Suntory Ltd.Product Specifications
Molecular Weight
294.31
Formula
C17H14N2O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
CAS Number
179068-02-1
PubChem ID
5866327
InChI Key
FPXPIEZPAXSELW-CYVLTUHYSA-N
SMILES
O=C(NC4=CC=CC=C4)C3(C2C3)OC1=CC=CC=C1/C2=N/O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.43 | 100 |
Preparing Stock Solutions
for PHCCC
The following data is based on the product molecular weight 294.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.40 mL | 16.99 mL | 33.98 mL |
| 5 mM | 0.68 mL | 3.40 mL | 6.80 mL |
| 10 mM | 0.34 mL | 1.70 mL | 3.40 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Flor Positive allosteric modulators of metabotropic glutamate receptor subtype 4: pharmacological and molecular characterization. Neuropharmacology
- Marino Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc.Natl.Acad.Sci.USA 2003 PMID: 14593202
- Annoura A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett.
- Mao and Wang Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P and preproenkephalin mRNA expression in rat dorsal striatum. Synapse 2001 PMID: 11071713
Product Specific Notices for PHCCC
For research use only
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