AZD 2066
Tocris Bioscience, part of Bio-Techne | Catalog # 5614
mGlu5 antagonist; orally bioavailable and brain penetrant
Key Product Details
Description
mGlu5 antagonist; orally bioavailable and brain penetrant
Product Description
AZD 2066 is an mGlu5 antagonist. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.Product Specifications
Molecular Weight
381.82
Formula
C19H16ClN5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine
CAS Number
934282-55-0
PubChem ID
16041426
InChI Key
SXWHYTICXCLKDG-GFCCVEGCSA-N
SMILES
CN1C(C2=CC=NC=C2)=NN=C1O[C@H](C)C3=NOC(C4=CC=CC(Cl)=C4)=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.18 | 100 | |
| Ethanol | 38.18 | 100 |
Preparing Stock Solutions
for AZD 2066
The following data is based on the product molecular weight 381.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.10 mL | 26.19 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Swedberg AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J.Pharmacol.Exp.Ther. 2014 PMID: 24876235
Product Specific Notices for AZD 2066
For research use only
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