VU 0360172 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4323

Positive allosteric modulator of mGlu5 receptors
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Key Product Details

Description

Positive allosteric modulator of mGlu5 receptors

View all Group I mGluR Modulators »

Product Description

VU 0360172 hydrochloride is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

Product Specifications

Molecular Weight

330.78

Formula

C18H15FN2O.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride

CAS Number

1309976-62-2

PubChem ID

53384852

InChI Key

NBGAPTWZQXSEAA-UHFFFAOYSA-N

SMILES

FC1=CC=CC(C#CC2=CC=C(C(NC3CCC3)=O)C=N2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.54 50
Ethanol 8.27 25

Preparing Stock Solutions for VU 0360172 hydrochloride

The following data is based on the product molecular weight 330.78

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.05 mL 30.23 mL 60.46 mL
2.5 mM 1.21 mL 6.05 mL 12.09 mL
5 mM 0.60 mL 3.02 mL 6.05 mL
25 mM 0.12 mL 0.60 mL 1.21 mL

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Product Documents for VU 0360172 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VU 0360172 hydrochloride

For research use only

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