Ro 67-4853

Name: Ro 67-4853
Brand: Tocris Bioscience
SKU: 4347

Tocris Bioscience, part of Bio-Techne | Catalog # 4347

Citations (1)

COA / SDS

Positive allosteric modulator of group I mGlu receptors

Key Product Details

Description:	Positive allosteric modulator of group I mGlu receptors
Chemical Name:	(9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	325.36

View Full Technical Details for Ro 67-4853

Technical Data
Citations

Biological Activity for Ro 67-4853

Ro 67-4853 is a positive allosteric modulator of mGlu group I receptors (pEC₅₀ value is 7.16 for the rat mGlu_1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu₁ and rat mGlu₅. Enhances the effects of (S)-DHPG in CA3 neurons (EC₅₀ = 95 nM).

Technical Data for Ro 67-4853

M. Wt	325.36
Formula	C₁₉H₁₉NO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	302841-89-0
PubChem ID	9949202
InChi Key	RQBUXEUMZZQUFY-UHFFFAOYSA-N
Smiles	O=C(NC(OCCCC)=O)C2C3=C(C=CC=C3)OC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 67-4853

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.54	100

Preparing Stock Solutions for Ro 67-4853

The following data is based on the product molecular weight 325.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.07 mL	15.37 mL	30.74 mL
5 mM	0.61 mL	3.07 mL	6.15 mL
10 mM	0.31 mL	1.54 mL	3.07 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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References for Ro 67-4853

References are publications that support the biological activity of the product.

Hempstapat A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 2006 PMID: 16645124
Knoflach Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site. Proc.Natl.Acad.Sci. 2001 PMID: 11606768