AZD 9272

Name: AZD 9272
Brand: Tocris Bioscience
SKU: 5613

Tocris Bioscience, part of Bio-Techne | Catalog # 5613

Citations (3)

COA / SDS

Potent and selective mGlu5 antagonist; brain penetrant

Key Product Details

Description:	Potent and selective mGlu₅ antagonist; brain penetrant
Chemical Name:	3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	284.22

View Full Technical Details for AZD 9272

Technical Data
Citations

Biological Activity for AZD 9272

AZD 9272 is a potent and selective mGlu₅ antagonist (IC₅₀ values are 2.6 and 7.6 nM for rat and human receptors, respectively). Exhibits >3900-fold selectivity for mGlu₅ over other mGlu receptors. Also selective over a panel of other targets. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.

Technical Data for AZD 9272

M. Wt	284.22
Formula	C₁₄H₆F₂N₄O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	327056-26-8
PubChem ID	9838729
InChi Key	RBSPCALDSNXWEP-UHFFFAOYSA-N
Smiles	FC1=CC=C(C2=NOC(C3=CC(F)=CC(C#N)=C3)=N2)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 9272

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	14.21	50

Preparing Stock Solutions for AZD 9272

The following data is based on the product molecular weight 284.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.04 mL	35.18 mL	70.37 mL
2.5 mM	1.41 mL	7.04 mL	14.07 mL
5 mM	0.70 mL	3.52 mL	7.04 mL
25 mM	0.14 mL	0.70 mL	1.41 mL

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References for AZD 9272

References are publications that support the biological activity of the product.

Raboisson Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg.Med.Chem.Lett. 2012 PMID: 23046966
Swedberg and Raboisson AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J.Pharmacol.Exp.Ther. 2014 PMID: 24876235