LSN 2463359

Tocris Bioscience, part of Bio-Techne | Catalog # 5275

Potent and selective positive allosteric modulator of mGlu5 receptors
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Key Product Details

Description

Potent and selective positive allosteric modulator of mGlu5 receptors

View all Group I mGluR Modulators »

Product Description

LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908-induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.

Product Specifications

Molecular Weight

265.31

Formula

C16H15N3O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(1-Methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide

CAS Number

1401031-52-4

PubChem ID

72551298

InChI Key

STAFRSGTRKNXHF-UHFFFAOYSA-N

SMILES

O=C(NC(C)C)C(C=C2)=NC=C2C#CC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.53 100
Ethanol 5.31 20

Preparing Stock Solutions for LSN 2463359

The following data is based on the product molecular weight 265.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Documents for LSN 2463359

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LSN 2463359

For research use only

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