Co 101244 hydrochloride

Name: Co 101244 hydrochloride
Brand: Tocris Bioscience
SKU: 2456
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2456

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Citations (39)

COA / SDS

GluN2B-selective NMDA antagonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

GluN2B-selective NMDA antagonist

Alternative Names

PD 174494,Ro 63-1908

View all NMDA Receptor Antagonists »

Product Description

Co 101244 hydrochloride is a novel, potent and selective antagonist of GluN2B (formally NR2B)-containing NMDA receptors (IC₅₀ values are 0.043, > 100 and > 100 μM for GluN1A/2B (NR1A/2B), GluN1A/2A (NR1A/2A) and GluN1A/2C (NR1A/2C) subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications

Molecular Weight

377.91

Formula

C₂₁H₂₇NO₃.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol hydrochloride

CAS Number

193356-17-1

PubChem ID

6918426

InChI Key

WFFZHKKSIDENAJ-UHFFFAOYSA-N

SMILES

Cl.CC1=CC=C(CC2(O)CCN(CCOC3=CC=C(O)C=C3)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	37.79	100
	DMSO	18.9	50

Preparing Stock Solutions for Co 101244 hydrochloride

The following data is based on the product molecular weight 377.91

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.23 mL	26.46 mL
5 mM	0.53 mL	2.65 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.65 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Gill Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-MthD.-aspartate antagonist. J.Pharmacol.Exp.Ther. 2002 PMID: 12183650
Higgins Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition. Neuropharmacology 2003 PMID: 12604092
Zhou 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J.Med.Chem. 1999 PMID: 10425109