CHPG

Name: CHPG
Brand: Tocris Bioscience
SKU: 1049
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1049

(1)

Citations (133)

COA / SDS

mGlu5 selective agonist

Key Product Details

Description:	mGlu₅ selective agonist
Chemical Name:	(RS)-2-Chloro-5-hydroxyphenylglycine
Purity:	≥99% (HPLC)
Molecular Weight:	201.61

View Full Technical Details for CHPG

Technical Data
Citations / Reviews (1)

Biological Activity for CHPG

CHPG is a selective mGlu₅ metabotropic glutamate receptor agonist, completely inactive at mGlu_1a receptors expressed in CHO cells. Active in vivo.

Sodium Salt also available.

Technical Data for CHPG

M. Wt	201.61
Formula	C₈H₈NO₃Cl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	170846-74-9
PubChem ID	3645780
InChi Key	UNIDAFCQFPGYJJ-UHFFFAOYSA-N
Smiles	NC(C(O)=O)C1=CC(O)=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHPG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH	20.16	100

Preparing Stock Solutions for CHPG

The following data is based on the product molecular weight 201.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.96 mL	24.80 mL	49.60 mL
5 mM	0.99 mL	4.96 mL	9.92 mL
10 mM	0.50 mL	2.48 mL	4.96 mL
50 mM	0.10 mL	0.50 mL	0.99 mL

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Reconstitution Calculator

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References for CHPG

References are publications that support the biological activity of the product.

Ugolini Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurones. Neuropharmacology 1999 PMID: 10530818
Doherty (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu₅, but not mGlu₁, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 1997 PMID: 9144665
Salt Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 1999 PMID: 10455248
Bao Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 2001 PMID: 11743947