CHPG Sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 3695
Selective mGlu5 agonist; sodium salt of CHPG (Cat. No. 1049)
Key Product Details
Description
Selective mGlu5 agonist; sodium salt of CHPG (Cat. No. 1049)
Product Description
CHPG Sodium salt is a sodium salt of the selective mGlu5 agonist CHPG (Cat. No. 1049).Product Specifications
Molecular Weight
223.59
Formula
C8H7ClNNaO3
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
(RS)-2-Chloro-5-hydroxyphenylglycine sodium salt
CAS Number
1303993-73-8
PubChem ID
52974246
InChI Key
KZRZZIISUUINJT-UHFFFAOYSA-M
SMILES
[Na+].NC(C([O-])=O)C1=CC(O)=CC=C1Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.18 | 50 | |
| DMSO | 11.18 | 50 |
Preparing Stock Solutions
for CHPG Sodium salt
The following data is based on the product molecular weight 223.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 8.94 mL | 44.72 mL | 89.45 mL |
| 2.5 mM | 1.79 mL | 8.94 mL | 17.89 mL |
| 5 mM | 0.89 mL | 4.47 mL | 8.94 mL |
| 25 mM | 0.18 mL | 0.89 mL | 1.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Salt Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 1999 PMID: 10455248
- Bao Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 2001 PMID: 11743947
- Doherty (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 1997 PMID: 9144665
Product Specific Notices for CHPG Sodium salt
For research use only
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