121 results for "CRBN Small Molecules and Peptides" in Products
CRBN: Small Molecules and Peptides
Modulates cell surface expression of KCNT1 . May be involved in memory and learning
Cereblon Degrader (PROTAC®)
| Chemical Name: | N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide |
| Purity: | ≥98% (HPLC) |
Potent and selective cereblon Degrader (PROTAC®); cell-permeable
| Chemical Name: | (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥96% (HPLC) |
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control
| Chemical Name: | 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Negative control for dTAG-13 (Cat. No. 6605)
| Chemical Name: | 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester |
| Purity: | ≥97% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | 4-[(8-Aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
Potent GSK3 Degrader (PROTAC®)
| Chemical Name: | 3-Amino-6-(4-((4-(4-(1-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-1H-1,2,3-triazol-4-yl)butyl)piperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
| Chemical Name: | 9-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]nonanoic acid |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with amine on C5 for onward chemistry
| Chemical Name: | 5-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Potent and selective BTK Degrader (PROTAC®)
| Chemical Name: | 3-[[4-[1-[[1-[6-[[[(3S)-2,6-Dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-2-pyrazinecarboxamide |
| Purity: | ≥98% (HPLC) |
Binds cereblon; also TNF-α synthesis inhibitor
| Chemical Name: | N-(2,6-dioxo-3-piperidinyl)phthalimide |
| Purity: | ≥98% (HPLC) |
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
| Chemical Name: | 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione |
| Purity: | ≥98% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | 4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Chemical Name: | 4-[(4-Azidobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Chemical Name: | 4-[(5-Azidopentyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
| Chemical Name: | 7-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]heptanoic acid |
| Purity: | ≥95% (HPLC) |
α-synuclein Degrader (PROTAC®)
| Chemical Name: | 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide |
| Purity: | ≥98% (HPLC) |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | 3-[4-[[2-[2-(2-(2-Aminoethoxy)ethoxy]ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Chemical Name: | 4-[(6-Azidohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
| Alternate Names: | Pomalidomide - linker 3 |
| Chemical Name: | 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal alkyne for onward chemistry
| Alternate Names: | Thalidomide - linker 5 |
| Chemical Name: | 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Chemical Name: | 4-[(2-Azidoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 3-[[3-[4-(Piperidin-4-ylmethyl)piperazin-1-yl]phenyl]amino]piperidine-2,6-dione trihydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-6-[4-(4-piperidinylmethyl)-1-piperazinyl]-1H-isoindole-1,3(2H)-dione dihydrochloride |
| Purity: | ≥95% (HPLC) |
Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR
| Chemical Name: | 3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide |
| Purity: | ≥98% (HPLC) |
BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor
| Chemical Name: | 2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate |
| Purity: | ≥98% (HPLC) |
