Thalidomide 4'-ether-PEG2-alkyne
Tocris Bioscience, part of Bio-Techne | Catalog # 6686
Cereblon ligand with PEG linker and terminal alkyne for onward chemistry
Key Product Details
Description
Cereblon ligand with PEG linker and terminal alkyne for onward chemistry
Alternative Names
Thalidomide - linker 5
Product Description
Thalidomide 4'-ether-PEG2-alkyne is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with alkyne terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.This product has been recently renamed. The previous name for this product was Thalidomide - linker 5
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
400.38
Formula
C20H20N2O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione
CAS Number
2098487-52-4
PubChem ID
131988624
InChI Key
XJWGDRINRIEEJD-UHFFFAOYSA-N
SMILES
O=C1N(C(C2=C(C=CC=C12)OCCOCCOCC#C)=O)C3CCC(NC3=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Remillard Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 2017 PMID: 28418626
Product Specific Notices for Thalidomide 4'-ether-PEG2-alkyne
For research use only
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